Journal Article

Cellular Prion Protein and Amyloid-β Oligomers in Alzheimer’s Disease—Are There Connections?

Hachiya, Naomi, Adamska, Hanna, Bartoszewska, Elżbieta, Urban, Szymon, Kurpas, Donata, Beszłej, Jan Aleksander, Fułek, Katarzyna, Gachowska, Martyna, Fułek, Michał, Kurpiński, Tomasz, Leszek, Jerzy, Poręba, Rafał

2025

Overview

Alzheimer’s disease (AD) is the most common cause of dementia worldwide. Pathological deposits of neurotoxin proteins within the brain, such as amyloid-β and hyperphosphorylated tau tangles, are prominent features in AD. The prion protein (PrP) is involved in neurodegeneration via its conversion from the normal cellular form (PrPC) to the infection prion protein scrapie (PrPSc) form. Some studies indicated that post-translationally modified PrPC isoforms play a fundamental role in AD pathological progression. Several studies have shown that the interaction of Aβ oligomers (Aβos) with the N-terminal residues of the PrPC protein region appears critical for neuronal toxicity. PrPC-Aβ binding always occurs in AD brains and is never detected in non-demented controls, and the binding of Aβ aggregates to PrPC is restricted to the N-terminus of PrPC. In this study, we aimed to gather all of the recent information about the connections between PrPC and AD, with potential clinical implications.

• Publisher: MDPI AG,MDPI
• Subject: Advertising executives / Alzheimer Disease - metabolism / Alzheimer Disease - pathology / Alzheimer's disease / Amino acids / Amyloid beta-Peptides - metabolism / Animals / Behavior / Brain - metabolism / Brain - pathology / Dementia / Denmark / Development and progression / Disease / Diseases / Enzymes / Health aspects / Humans / Kinases / Memory / Nervous system / Neurons / Neurophysiology / Neurotoxicity / Older people / Oligomers / Oxidative stress / Pathogenesis / Pathology / Peptides / Phosphorylation / Poland / Prion Proteins - metabolism / Prions / Proteins / PrPC Proteins - metabolism / Review / Toxicity