Journal Article

Digestive Inflammation: Role of Proteolytic Dysregulation

Maguin, Emmanuelle, This work received funding from the Microbiology and the Food Chain division (MICA) of the INRAE Institute through the metaprogramme MEM-Meta-omics and microbial ecosystems, and Titan-ANR number ANR-18-CE18-0019-03 and SerpinGuTarget ANR-CE16-0018-01 project, the CMCU-PHC Utique (No. 19G0819)-Campus France (41786NC) and the Twinning European project MICAfrica 952583, Mariaule, Vincent, University of Gdańsk (UG), Rhimi, Moez, Kriaa, Aicha, European Project: 9525833, Boudaya, Houda, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS) ; AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Soussou, Souha, Lesner, Adam, Rhimi, Soufien, ANR-16-CE16-0018,EPITRACES,Traces épigénétiques neuronales des récompenses, Hernandez, Juan

2021

Overview

Dysregulation of the proteolytic balance is often associated with diseases. Serine proteases and matrix metalloproteases are involved in a multitude of biological processes and notably in the inflammatory response. Within the framework of digestive inflammation, several studies have stressed the role of serine proteases and matrix metalloproteases (MMPs) as key actors in its pathogenesis and pointed to the unbalance between these proteases and their respective inhibitors. Substantial efforts have been made in developing new inhibitors, some of which have reached clinical trial phases, notwithstanding that unwanted side effects remain a major issue. However, studies on the proteolytic imbalance and inhibitors conception are directed toward host serine/MMPs proteases revealing a hitherto overlooked factor, the potential contribution of their bacterial counterpart. In this review, we highlight the role of proteolytic imbalance in human digestive inflammation focusing on serine proteases and MMPs and their respective inhibitors considering both host and bacterial origin.

• Publisher: MDPI,CCSD,MDPI AG
• Subject: Animals / Biochemistry, Molecular Biology / Chemokines / Disease / Enzymes / Gene expression / Homeostasis / Humans / Inflammation / Inflammation - enzymology / Inflammation - pathology / Inflammatory bowel disease / Inflammatory Bowel Diseases - enzymology / Inflammatory Bowel Diseases - pathology / Kinases / Life Sciences / Matrix Metalloproteinases - metabolism / Microbiology and Parasitology / Microbiota / Neutrophils / Pathogenesis / Peptides / Permeability / Proteolysis / Review / Serine Proteases - metabolism / Tumor necrosis factor-TNF
• ISBN: 0006457192000