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Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of Current Therapies

by García, Samuel , Pego-Reigosa, José M. , Martínez-Ramos, Sara , Rafael-Vidal, Carlos

in Ankylosing spondylitis / Antigens / Arthritis / current therapies / Cytokines / Endoplasmic reticulum / Epigenetics / Gene expression / Histocompatibility antigen HLA / HLA-B27 Antigen - genetics / Humans / Hypotheses / Immune system / Inflammation / Inflammatory bowel disease / Inflammatory bowel diseases / Inflammatory diseases / Innate immunity / Joint diseases / Lymphocytes / Macrophages / Macrophages - pathology / Microbiota / Monocytes / Monocytes - pathology / Pathogenesis / Pathogens / Peptides / Proteins / Psoriasis / Psoriatic arthritis / Review / Rheumatic diseases / Spondylarthritis - pathology / Spondylarthritis - therapy / Spondylitis, Ankylosing - pathology / Spondylitis, Ankylosing - therapy / spondyloarthritis / Uveitis

2022

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Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of Current Therapies

by García, Samuel , Pego-Reigosa, José M. , Martínez-Ramos, Sara , Rafael-Vidal, Carlos

2022

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Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of Current Therapies

by García, Samuel , Pego-Reigosa, José M. , Martínez-Ramos, Sara , Rafael-Vidal, Carlos

2022

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Journal Article

Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of Current Therapies

García, Samuel,

Pego-Reigosa, José M.,

Martínez-Ramos, Sara,

Rafael-Vidal, Carlos

2022

Overview

Spondyloarthritis (SpA) is a family of chronic inflammatory diseases, being the most prevalent ankylosing spondylitis (AS) and psoriatic arthritis (PsA). These diseases share genetic, clinical and immunological features, such as the implication of human leukocyte antigen (HLA) class I molecule 27 (HLA-B27), the inflammation of peripheral, spine and sacroiliac joints and the presence of extra-articular manifestations (psoriasis, anterior uveitis, enthesitis and inflammatory bowel disease). Monocytes and macrophages are essential cells of the innate immune system and are the first line of defence against external agents. In rheumatic diseases including SpA, the frequency and phenotypic and functional characteristics of both cell types are deregulated and are involved in the pathogenesis of these diseases. In fact, monocytes and macrophages play key roles in the inflammatory processes characteristics of SpA. The aim of this review is analysing the characteristics and functional roles of monocytes and macrophages in these diseases, as well as the impact of different current therapies on these cell types.

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Publisher

MDPI AG,MDPI

Subject

Ankylosing spondylitis

/ Endoplasmic reticulum

/ Epigenetics