Asset Details
Do you wish to reserve the book?
The molecular landscape of head and neck cancer
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The molecular landscape of head and neck cancer
Do you wish to request the book?
The molecular landscape of head and neck cancer
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The molecular landscape of head and neck cancer
2018
Overview
Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the upper aerodigestive tract and are unexpectedly heterogeneous in nature. Classical risk factors are smoking and excessive alcohol consumption, and in recent years, the role of human papillomavirus (HPV) has emerged, particularly in oropharyngeal tumours. HPV-induced oropharyngeal tumours are considered a separate disease entity, which recently has manifested in an adapted prognostic staging system while the results of de-intensified treatment trials are awaited. Carcinogenesis caused by HPV in the mucosal linings of the upper aerodigestive tract remains an enigma, but with some recent observations, a model can be proposed. In 2015, The Cancer Genome Atlas (TCGA) consortium published a comprehensive molecular catalogue on HNSCC. Frequent mutations of novel druggable oncogenes were not demonstrated, but the existence of a subgroup of genetically distinct HPV-negative head and neck tumours with favourable prognoses was confirmed. Tumours can be further subclassified based on genomic profiling. However, the amount of molecular data is currently overwhelming and requires detailed biological interpretation. It also became apparent that HNSCC is a disease characterized by frequent mutations that create neoantigens, indicating that immunotherapies might be effective. In 2016, the first results of immunotherapy trials with immune checkpoint inhibitors were published, and these may be considered as a paradigm shift in head and neck oncology.
Publisher
Nature Publishing Group
Subject
/ Biomarkers, Tumor - analysis
/ Cancer
/ Cyclin-Dependent Kinase Inhibitor p16 - analysis
/ Gene Expression Regulation, Neoplastic
/ Genomes
/ Head
/ Head and Neck Neoplasms - genetics
/ Head and Neck Neoplasms - pathology
/ Head and Neck Neoplasms - virology
/ Humans
/ Linings
/ Mucosa
/ Mutation
/ Oropharyngeal Neoplasms - pathology
/ Oropharyngeal Neoplasms - virology
/ Papillomavirus Infections - complications
/ Smoking
/ Squamous Cell Carcinoma of Head and Neck - genetics
/ Squamous Cell Carcinoma of Head and Neck - pathology
/ Squamous Cell Carcinoma of Head and Neck - virology
/ Tumors
