Journal Article

Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease

Wei, Lai, Liu, Feng, Wu, Chaodong, Li, Honggui, Rao, Huiying, Wang, Xiaoxiao

2021

Overview

Obesity is a serious ongoing health problem that significantly increases the incidence of nonalcoholic fatty liver disease (NAFLD). During obesity, adipose tissue dysfunction is obvious and characterized by increased fat deposition (adiposity) and chronic low-grade inflammation. The latter has been implicated to critically promote the development and progression of NAFLD, whose advanced form non-alcoholic steatohepatitis (NASH) is considered one of the most common causes of terminal liver diseases. This review summarizes the current knowledge on obesity-related adipose dysfunction and its roles in the pathogenesis of hepatic steatosis and inflammation, as well as liver fibrosis. A better understanding of the crosstalk between adipose tissue and liver under obesity is essential for the development of new and improved preventive and/or therapeutic approaches for managing NAFLD.

• Publisher: MDPI AG,MDPI
• Subject: adipose dysfunction / Adipose tissue / Adipose Tissue - physiopathology / Body fat / Body mass index / crosstalk / Diabetes / Fatty liver / Fibrosis / Glucose / Hepatitis / Human subjects / Humans / Hyperplasia / Inflammation / Inflammation - pathology / Insulin resistance / Lipids / Liver diseases / Metabolic disorders / Models, Biological / Non-alcoholic Fatty Liver Disease - etiology / Non-alcoholic Fatty Liver Disease - physiopathology / nonalcoholic fatty liver disease (NAFLD) / Obesity / Obesity - complications / Oils & fats / Overweight / Pathogenesis / Pathophysiology / Review / Signal Transduction / Steatosis / Tumor necrosis factor-TNF