Journal Article

A Nonsimultaneous, Extended, Altruistic-Donor Chain

Pelletier, Ronald P, Hiller, Janet, Sandholm, Tuomas, Fabrega, Alfredo J, Rogers, Jeffrey, Pankewycz, Oleh G, Ünver, M. Utku, Rees, Michael A, Montgomery, Robert A, Rutter, Matthew E, Kopke, Jonathan E, Segev, Dorry L, Roth, Alvin E

2009

Overview

The authors report a nonsimultaneous chain of 10 kidney transplantations, which was initiated in July 2007 by a single altruistic donor and involved six transplantation centers in five states. This strategy, coordinated by two large, paired-donation registries with the use of powerful computer programs, can potentially result in more kidney transplantations. The authors report a nonsimultaneous chain of 10 kidney transplantations, which was initiated in July 2007 by a single altruistic donor and involved six transplantation centers in five states. This strategy can potentially result in more kidney transplantations. Paired kidney donation is an evolving strategy for overcoming the barriers that confront patients with end-stage renal disease when the only living potential donors who are willing to donate to them are deemed to be unsuitable as donors for them owing to an incompatibility of blood type, of HLA crossmatch, or of both. In the most basic form of paired donation, the incompatibility problems with two donor–recipient pairs can be solved by exchanging donors. 1 – 3 Using advanced software, several organizations have arranged paired kidney donations involving three or more pairs. 4 , 5 Recent reports describe simultaneously performed “domino transplantations” initiated by . . .

• Publisher: Massachusetts Medical Society
• Subject: ABO Blood-Group System - immunology / Adult / Altruism / Biological and medical sciences / Female / General aspects / Histocompatibility Testing / Humans / Kidney Transplantation / Living Donors / Male / Medical sciences / Middle Aged / Tissue and Organ Procurement - methods / Tissue and Organ Procurement - organization & administration