Journal Article

COVID-19 Vaccine in Lung and Liver Transplant Recipients Exceeds Expectations: An Italian Real-Life Experience on Immunogenicity and Clinical Efficacy of BNT162b2 Vaccine

Ceriotti, Ferruccio, Giacomel, Giovanni, Rossetti, Valeria, Donato, Maria Francesca, Dibenedetto, Clara, Lampertico, Pietro, Morlacchi, Letizia Corinna, Uceda Renteria, Sara, Lombardi, Andrea, Antonelli, Barbara, Blasi, Francesco, Rosso, Lorenzo, Alicandro, Gianfranco, Zignani, Nunzio, Sagasta, Michele, Citterio, Gaia

2024

Overview

This study assessed humoral and T cell-mediated immune responses to the BNT162b2 vaccine in orthotopic liver transplant (OLT) and lung transplant (LUT) recipients who received three doses of the vaccine from March 2021 at our institution. Serum samples were collected 60 days post-second and third dose to quantify antibodies against the spike region of SARS-CoV-2 while whole blood samples were collected to analyze the SARS-CoV-2-specific T-cell response using an IFN-γ ELISpot assay. We enrolled 244 OLT and 120 LUT recipients. The third dose increased antibody titres in OLT recipients (from a median value of 131 after the second dose to 5523 IU/mL, p < 0.001) and LUT recipients (from 14.8 to 1729 IU/mL, p < 0.001). T-cell response also increased in OLT recipients (from 8.5 to 23 IFN-γ SFU per 250,000 PBMC, p < 0.001) and LUT recipients (from 8 to 15 IFN-γ SFU per 250,000 PBMC, p < 0.001). A total of 128 breakthrough infections were observed: two (0.8%) OLT recipients were hospitalized due to COVID-19 and one died (0.4%); among LUT recipients, seven were hospitalized (5.8%) and two patients died (1.7%). In conclusion, the three-dose schedule of the BNT162b2 vaccine elicited both humoral and T cell-mediated responses in solid organ transplant recipients. The risk of severe COVID-19 post-vaccination was low in this population.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Adult / Aged / Antibodies / Antibodies, Viral - blood / BNT162 Vaccine - immunology / Body mass index / COVID-19 / COVID-19 - immunology / COVID-19 - prevention & control / COVID-19 vaccination / COVID-19 vaccines / COVID-19 Vaccines - immunology / Enzyme-linked immunosorbent assay / Female / Health Archive / Humans / humoral response / Immune response (cell-mediated) / Immune response (humoral) / Immunity, Cellular / Immunity, Humoral / Immunization / Immunogenicity / Immunogenicity, Vaccine / Italy / Liver / liver transplant recipients / Liver Transplantation / lung transplant recipients / Lung Transplantation / Lungs / Lymphocytes / Lymphocytes T / Male / Middle Aged / Peripheral blood mononuclear cells / SARS-CoV-2 - immunology / Severe acute respiratory syndrome coronavirus 2 / Skin cancer / solid organ transplant recipient / T-Lymphocytes - immunology / Transplant Recipients / vaccine immunogenicity / Vaccines / γ-Interferon