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Membrane Damage Effect of Therapeutic Ultrasound on Ehrlich Ascitic Tumor Cells
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Membrane Damage Effect of Therapeutic Ultrasound on Ehrlich Ascitic Tumor Cells
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Journal Article
Membrane Damage Effect of Therapeutic Ultrasound on Ehrlich Ascitic Tumor Cells
2009
Overview
Purpose:
The biologic effects and the underlying mechanisms of Ehrlich ascitic tumor (EAT) cells induced by ultrasound were investigated in this study.
Methods:
Cells were subjected to ultrasonic irradiation with a frequency of 2.17 MHz and an intensity of 3 W/cm2 for variable periods of time. Trypan blue exclusion was used to detect the integrity of cellular membrane; the membrane permeability was investigated by the incorporation of fluorescein isothiocyanate dextran during ultrasound exposure; and the cell membrane ultrastructure changes were observed under a scanning electron microscope. The potential mechanism was estimated from the generation of hydroxyl radicals, the lipid peroxidation levels, and intracellular reactive oxygen radicals production.
Results:
The cell membrane damage effects induced by ultrasound increased with a prolonged exposure time; the fluorescent rates of the cells irradiated with ultrasound for 30 and 60 seconds were 11.46% and 18.50%, respectively; the amount of hydroxyl radicals in 30 (26.10 U/mL) and 60 seconds (28.47 U/mL) were significantly enhanced, compared with the control group (24.44 U/mL); then, the level of lipid peroxidation was also changed from 0.27 to 0.54 (30 seconds) and 1.21 nmol/mL (60 seconds).
Conclusions:
Shear forces and free radicals produced by acoustic cavitation may play important roles in these actions.
Publisher
SAGE Publications,Mary Ann Liebert, Inc
