Journal Article

Data-driven, generalizable prediction of adolescent sleep disturbances in the multisite Adolescent Brain Cognitive Development Study

Toda-Thorne, Katherine, Taxali, Aman, McCurry, Katherine L, Sripada, Chandra, Hardi, Felicia A, Angstadt, Mike, Heitzeg, Mary M

2024

Overview

Sleep disturbances are common in adolescence and associated with a host of negative outcomes. Here, we assess associations between multifaceted sleep disturbances and a broad set of psychological, cognitive, and demographic variables using a data-driven approach, canonical correlation analysis (CCA). Baseline data from 9093 participants from the Adolescent Brain Cognitive Development (ABCD) Study were examined using CCA, a multivariate statistical approach that identifies many-to-many associations between two sets of variables by finding combinations for each set of variables that maximize their correlation. We combined CCA with leave-one-site-out cross-validation across ABCD sites to examine the robustness of results and generalizability to new participants. The statistical significance of canonical correlations was determined by non-parametric permutation tests that accounted for twin, family, and site structure. To assess the stability of the associations identified at baseline, CCA was repeated using 2-year follow-up data from 4247 ABCD Study participants. Two significant sets of associations were identified: (1) difficulty initiating and maintaining sleep and excessive daytime somnolence were strongly linked to nearly all domains of psychopathology (r2 = 0.36, p < .0001); (2) sleep breathing disorders were linked to BMI and African American/black race (r2 = 0.08, p < .0001). These associations generalized to unseen participants at all 22 ABCD sites and were replicated using 2-year follow-up data. These findings underscore interwoven links between sleep disturbances in early adolescence and psychological, social, and demographic factors.

• Publisher: Oxford University Press
• Subject: Adolescence / Adolescent / Adolescent Development - physiology / Brain / Child development / Cognition - physiology / Cognitive development / Disorders of Excessive Somnolence - epidemiology / Editor's Choice / Female / Humans / Male / Medical research / Medicine, Experimental / Psychology, Pathological / Sleep / Sleep Across the Lifespan / Sleep disorders / Sleep Initiation and Maintenance Disorders / Sleep Wake Disorders - epidemiology / Teenagers