Journal Article

Clinical profile and treatment outcomes of idiopathic intracranial hypertension: a multicenter study from Korea

Seo, Jong-Geun, Kim, Sung-Hee, Chu, Min Kyung, Oh, Sun-Young, Kim, Byung-Su, Kang, Mi-Kyoung, Cho, Kyung-Hee, Lee, Ju-Young, Lee, Sang-Hwa, Baek, Seol-Hee, Park, Hong-Kyun, Sohn, Jong-Hee, Cho, Soohyun, Mo, Hee Jung, Lee, Mi Ji, Lee, Wonwoo, Cho, Soo-Jin

2024

Overview

Background Currently, there is a relative lack of detailed reports regarding clinical presentation and outcome of idiopathic intracranial hypertension in Asians. This study aims to describe the clinical features and treatment outcomes of Korean patients with idiopathic intracranial hypertension. Methods We prospectively recruited patients with idiopathic intracranial hypertension from one hospital and retrospectively analyzed the medical records of 11 hospitals in Korea. We collected data regarding preceding medical conditions or suspected medication exposure, headache phenotypes, other associated symptoms, detailed neuroimaging findings, treatments, and outcomes after 1–2 and 3–6 months of treatment. Results Fifty-nine (83.1% women) patients were included. The mean body mass index was 29.11 (standard deviation, 5.87) kg/m 2 ; only 27 patients (45.8%) had a body mass index of ≥ 30 kg/m 2 . Fifty-one (86.4%) patients experienced headaches, patterns of which included chronic migraine (15/51 [29.4%]), episodic migraine (8/51 [15.7%]), probable migraine (4/51 [7.8%]), chronic tension-type headache (3/51 [5.9%]), episodic tension-type headache (2/51 [3.9%]), probable tension-type headache (2/51 [3.9%]), and unclassified (17/51 [33.3%]). Medication overuse headache was diagnosed in 4/51 (7.8%) patients. After 3–6 months of treatment, the intracranial pressure normalized in 8/32 (25.0%), improved in 17/32 (53.1%), no changed in 7/32 (21.9%), and worsened in none. Over the same period, headaches remitted or significantly improved by more than 50% in 24/39 patients (61.5%), improved less than 50% in 9/39 (23.1%), and persisted or worsened in 6/39 (15.4%) patients. Conclusion Our findings suggest that the features of Asian patients with idiopathic intracranial hypertension may be atypical (i.e., less likely obese, less female predominance). A wide spectrum of headache phenotypes was observed. Medical treatment resulted in overall favorable short-term outcomes; however, the headaches did not improve in a small proportion of patients.

• Publisher: Springer Milan,Springer Nature B.V,BMC
• Subject: Adult / Asian / Body mass index / Clinical outcomes / Female / Headache / Headaches / Humans / Hypertension / Internal Medicine / Intracranial hypertension / Intracranial pressure / Male / Medical records / Medical treatment / Medicine / Medicine & Public Health / Middle Aged / Migraine / Neuroimaging / Neurology / Pain Medicine / Papilledema / Patients / Phenotypes / Prospective Studies / Pseudotumor cerebri / Pseudotumor Cerebri - diagnosis / Pseudotumor Cerebri - drug therapy / Pseudotumor Cerebri - therapy / Republic of Korea - epidemiology / Retrospective Studies / Treatment Outcome / Young Adult