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CD27 is not an ideal marker for human memory B cells and can be modulated by IL-21 upon stimulated by Anti-CD40
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CD27 is not an ideal marker for human memory B cells and can be modulated by IL-21 upon stimulated by Anti-CD40
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Journal Article
CD27 is not an ideal marker for human memory B cells and can be modulated by IL-21 upon stimulated by Anti-CD40
2024
Overview
B cells play a key role in humoral immune responses by producing antibodies. Although there are numerous research on memory B cells definition markers and cytokines on B cell development, different studies have yielded contradictory conclusions due to species studied, the different cells and stimulating agents used. In the current study, we conducted a detailed characterization of B cells in human CBMCs, PBMCs and tonsil, including expression of Igs, activation and memory markers. Furthermore, we found that considerable amounts of IgA and IgG were expressed by CD27
−
B cells. These “Atypical” memory B cells corresponded to approximately 50% of IgG
+
and IgA
+
B cells in blood, this proportion even reached 90% in tonsil. In addition, we investigated the effect of IL-21 and TGF-β1 on the membrane-bound form and secreted form of Igs using PBMCs and purified blood B cells. There were actual differences between the effect of cytokines on Igs secretion and surface expression. Our study will be helpful to advance the knowledge and understanding of humoral memory.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ B-Lymphocytes - drug effects
/ Blood
/ CD27
/ Humanities and Social Sciences
/ Humans
/ IL-21
/ Immunoglobulin A - immunology
/ Immunoglobulin A - metabolism
/ Immunoglobulin G - immunology
/ Immunologic Memory - drug effects
/ Leukocytes, Mononuclear - drug effects
/ Leukocytes, Mononuclear - immunology
/ Leukocytes, Mononuclear - metabolism
/ Lymphocyte Activation - drug effects
/ Palatine Tonsil - immunology
/ Palatine Tonsil - metabolism
/ Science
/ TGF-β
/ Tonsil
/ Transforming Growth Factor beta1 - metabolism
/ Transforming growth factor-b1
/ Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism
