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Role of mucosal-associated invariant T cells dynamics in pathogenesis of Sjögren syndrome

by Chevalier, Mathieu F. , Chauffier, Jeanne , Comarmond, Cloé , Bigot, William , Caillat-Zucman, Sophie , Amador-Borrero, Blanca , Kaci, Rachid , Selvanadin, Aurélie , Mouly, Stéphane , Berger de Gallardo, Henri , Adle-Biassete, Homa , Champion, Karine , Coudert, Amélie , Aldersons, Elisa , Lambert, Marion , Sène, Damien , Cohen-Solal, Martine , Kante, Aïcha , Burlacu, Ruxandra , Cabrol, Xavier

in 631/80/304 / 692/4023 / 692/420 / Autoimmune diseases / Biopsy / CD4 antigen / CD69 antigen / CD8 antigen / Cell activation / Cytotoxicity / Homeostasis / Humanities and Social Sciences / Lacrimal gland and Nasolacrimal duct / Lymphocytes T / Mucosa / multidisciplinary / Peripheral blood / Phenotypes / Salivary gland / Science / Science (multidisciplinary) / Sjogren's syndrome / Tumor necrosis factor-α / γ-Interferon

2024

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Role of mucosal-associated invariant T cells dynamics in pathogenesis of Sjögren syndrome

2024

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2024

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Journal Article

Role of mucosal-associated invariant T cells dynamics in pathogenesis of Sjögren syndrome

Chevalier, Mathieu F.,

Chauffier, Jeanne,

Comarmond, Cloé,

Bigot, William,

Caillat-Zucman, Sophie,

Amador-Borrero, Blanca,

Kaci, Rachid,

Selvanadin, Aurélie,

Mouly, Stéphane,

Berger de Gallardo, Henri,

Adle-Biassete, Homa,

Champion, Karine,

Coudert, Amélie,

Aldersons, Elisa,

Lambert, Marion,

Sène, Damien,

Cohen-Solal, Martine,

Kante, Aïcha,

Burlacu, Ruxandra,

Cabrol, Xavier

2024

Overview

Sjögren syndrome (SS) is an autoimmune disease characterized by chronic inflammatory infiltrates in the salivary and lacrimal glands. Mucosal-associated invariant T (MAIT) cells are a subset of innate-like T-cells, predominantly found in mucosal tissues with crucial role in epithelial homeostasis. Thus, MAIT cells may be implicated in mucosal alterations of SS patients. Activation markers, inflammatory and cytotoxic cytokines were examined in 23 SS patients and compared to 23 healthy controls (HC). Tissular MAIT cells in salivary gland (SG) biopsies were also analyzed. Circulating MAIT cells were decreased in SS patients with a higher expression of CD69 and a higher CD4/CD8 ratio of MAIT cells. MAIT cells showed a higher production of IFNγ, TNFα and GzB in SS compare to HC. Tissular MAIT cells were present within inflamed SG of SS patients, while they were absent in SG of HC. Overall, circulating MAIT cells are decreased in the peripheral blood of SS albeit producing higher amounts of IFNγ, TNFα, and GzB. Tissular MAIT cells are detected in salivary glands from SS with a proinflammatory tissular cytokine environment. MAIT cells with abnormal phenotype, functions and tissular homeostasis may contribute to epithelial damage in SS.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

631/80/304

/ 692/4023

/ 692/420

/ Autoimmune diseases

/ Biopsy

/ CD4 antigen

/ CD69 antigen