Asset Details
Do you wish to reserve the book?
Laboratory Characterization of Measles Virus Infection in Previously Vaccinated and Unvaccinated Individuals
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Laboratory Characterization of Measles Virus Infection in Previously Vaccinated and Unvaccinated Individuals
Do you wish to request the book?
Laboratory Characterization of Measles Virus Infection in Previously Vaccinated and Unvaccinated Individuals
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Laboratory Characterization of Measles Virus Infection in Previously Vaccinated and Unvaccinated Individuals
2011
Overview
Waning immunity or secondary vaccine failure (SVF) has been anticipated by some as a challenge to global measles elimination efforts. Although such cases are infrequent, measles virus (MeV) infection can occur in vaccinated individuals following intense and/or prolonged exposure to an infected individual and may present as a modified illness that is unrecognizable as measles outside of the context of a measles outbreak. The immunoglobulin M response in previously vaccinated individuals may be nominal or fleeting, and viral replication may be limited. As global elimination proceeds, additional methods for confirming modified measles cases may be needed to understand whether SVF cases contribute to continued measles virus (MeV) transmission. In this report, we describe clinical symptoms and laboratory results for unvaccinated individuals with acute measles and individuals with SVF identified during MeV outbreaks. SVF cases were characterized by the serological parameters of high-avidity antibodies and distinctively high levels of neutralizing antibody. These parameters may represent useful biomarkers for classification of SVF cases that previously could not be confirmed as such using routine laboratory diagnostic techniques.
Publisher
Oxford University Press
Subject
/ Child
/ Dosage
/ Humans
/ Infant
/ Measels mumps rubella vaccine
/ Measles
/ Measles - prevention & control
/ Measles Vaccine - administration & dosage
/ Measles Vaccine - immunology
/ Measles virus - classification
/ MOLECULAR EPIDEMIOLOGY AND LABORATORY ASPECTS OF MEASLES AND RUBELLA SURVEILLANCE
