Journal Article

Cabozantinib After a Previous Immune Checkpoint Inhibitor in Metastatic Renal Cell Carcinoma: A Retrospective Multi-Institutional Analysis

Iacovelli, Roberto, Masini, Cristina, Maruzzo Marco, Milella, Michele, Fable, Zustovich, Bracarda Sergio, Tortora Giampaolo, Urbano Federica, Facchini Gaetano, Basso Umberto, Cortesi Enrico, De Giorgi Ugo, Santini Daniele, Massari, Francesco, Berardi Rossana, Santoni Matteo, Rossetti, Sabrina, De Tursi Michele, Buti Sebastiano, Ciccarese Chiara, Sepe Pierangela, Sabbatini, Roberto, Ricotta Riccardo, Procopio Giuseppe

2020

Overview

BackgroundAngiogenesis has been recognized as the most important factor for tumor invasion, proliferation, and progression in metastatic renal cell carcinoma (mRCC). However, few clinical data are available regarding the efficacy of cabozantinib following immunotherapy.ObjectiveTo describe the outcome of cabozantinib in patients previously treated with immunotherapy.Patients and methodsPatients with mRCC who received cabozantinib immediately after nivolumab were included. The primary endpoint was to assess the outcome in terms of efficacy and activity.ResultsEighty-four mRCC patients met the criteria to be included in the final analysis. After a median follow-up of 9.4 months, median overall survival was 17.3 months. According to the IMDC criteria, the rates of patients alive at 12 months in the good, intermediate, and poor prognostic groups were 100%, 74%, and 33%, respectively (p < 0.001). The median progression-free survival (PFS) was 11.5 months (95% CI 8.3–14.7); no difference was found based on duration of previous first-line therapy or nivolumab PFS. The overall response rate was 52%, stable disease was found as the best response in 25.3% and progressive disease in 22.7% of patients. Among the 35 patients with progressive disease on nivolumab, 26 (74.3%) patients showed complete/partial response or stable disease with cabozantinib as best response after nivolumab. The major limitations of this study are the retrospective nature and the short follow-up.ConclusionsCabozantinib was shown to be effective and active in patients previously receiving immune checkpoint inhibitors. Therefore, cabozantinib can be considered a valid therapeutic option for previously treated mRCC patients, irrespective of the type and duration of prior therapies.

• Publisher: Springer Nature B.V
• Subject: Immune checkpoint inhibitors / Immunotherapy / Inhibitor drugs / Kidney cancer / Metastasis / Monoclonal antibodies / Targeted cancer therapy