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Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells
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Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells
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Journal Article
Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells
2006
Overview
Biosynthesis of heparin, a mast cell–derived glycosaminoglycan with widespread importance in medicine, has not been fully elucidated. In biosynthesis of heparan sulfate (HS), a structurally related polysaccharide, HS glucuronyl C5-epimerase (Hsepi) converts
D
-glucuronic acid (GlcA) to
L
-iduronic acid (IdoA) residues. We have generated
Hsepi
-null mouse mutant mast cells, and we show that the same enzyme catalyzes the generation of IdoA in heparin and that 'heparin' lacking IdoA shows a distorted
O
-sulfation pattern.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Carbohydrate Epimerases - chemistry
/ Carbohydrate Epimerases - metabolism
/ Carbohydrate Epimerases - physiology
/ Carbohydrate Epimerases/chemistry/metabolism/physiology
/ Enzymes
/ Heparan Sulfate Proteoglycans - chemistry
/ Heparin/biosynthesis/chemistry
/ Heparitin Sulfate - chemistry
/ Humans
/ Mice
/ Rodents
/ Sulfates
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