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Origin and cross-species transmission of bat coronaviruses in China
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Origin and cross-species transmission of bat coronaviruses in China
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Origin and cross-species transmission of bat coronaviruses in China
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Journal Article
Origin and cross-species transmission of bat coronaviruses in China
2024
Overview
Bats are presumed reservoirs of diverse coronaviruses (CoVs) including progenitors of Severe Acute Respiratory Syndrome (SARS)-CoV and SARS-CoV-2, the causative agent of COVID-19. However, the evolution and diversification of these coronaviruses remains poorly understood. Here we use a Bayesian statistical framework and a large sequence data set from bat-CoVs (including 589 novel CoV sequences) in China to study their macroevolution, cross-species transmission and dispersal. We find that host-switching occurs more frequently and across more distantly related host taxa in alpha- than beta-CoVs, and is more highly constrained by phylogenetic distance for beta-CoVs. We show that inter-family and -genus switching is most common in Rhinolophidae and the genus
Rhinolophus
. Our analyses identify the host taxa and geographic regions that define hotspots of CoV evolutionary diversity in China that could help target bat-CoV discovery for proactive zoonotic disease surveillance. Finally, we present a phylogenetic analysis suggesting a likely origin for SARS-CoV-2 in
Rhinolophus
spp. bats.
Bats are a likely reservoir of zoonotic coronaviruses (CoVs). Here, analyzing bat CoV sequences in China, the authors find that alpha-CoVs have switched hosts more frequently than betaCoVs, identify a bat family and genus that are highly involved in host-switching, and define hotspots of CoV evolutionary diversity.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/77
/ 45/91
/ Alphacoronavirus - classification
/ Alphacoronavirus - isolation & purification
/ Animals
/ Betacoronavirus - classification
/ Betacoronavirus - isolation & purification
/ Coronavirus - classification
/ Coronavirus - isolation & purification
/ Coronavirus Infections - epidemiology
/ Coronavirus Infections - transmission
/ Coronavirus Infections - veterinary
/ Coronavirus Infections - virology
/ COVID-19
/ Disease Reservoirs - virology
/ Humanities and Social Sciences
/ Humans
/ SARS-CoV-2 - isolation & purification
/ Science
/ Severe acute respiratory syndrome coronavirus 2
/ Taxa
/ Zoonoses
