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The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control

by Deng, Jinhai , Suwaidan, Ali Abdulnabi , Yin, Mingzhu , Vicencio, Jose M , Beatson, Richard , McCarthy, Caitlin , Alfano, Giovanna , Liu, Zaoqu , Pan, Teng , Cao, Lulu , Ng, Tony

in Apoptosis / Bladder cancer / Bone cancer / Breast cancer / Cell cycle / Cell growth / Cervical cancer / Chemotherapy / Disease / DNA damage / DNA methylation / Gastric cancer / Glucose metabolism / Hospitals / Immunology / Kidney cancer / Lipid metabolism / Liver cancer / Lung cancer / Medical prognosis / Medical research / Melanoma / Metabolism / Metastasis / Oxidation / Therapeutic targets / Thioredoxin / Tumor microenvironment / Tumorigenesis / Tumors

2023

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The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control

by Deng, Jinhai , Suwaidan, Ali Abdulnabi , Yin, Mingzhu , Vicencio, Jose M , Beatson, Richard , McCarthy, Caitlin , Alfano, Giovanna , Liu, Zaoqu , Pan, Teng , Cao, Lulu , Ng, Tony

2023

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The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control

by Deng, Jinhai , Suwaidan, Ali Abdulnabi , Yin, Mingzhu , Vicencio, Jose M , Beatson, Richard , McCarthy, Caitlin , Alfano, Giovanna , Liu, Zaoqu , Pan, Teng , Cao, Lulu , Ng, Tony

2023

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Journal Article

The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control

Deng, Jinhai,

Suwaidan, Ali Abdulnabi,

Yin, Mingzhu,

Vicencio, Jose M,

Beatson, Richard,

McCarthy, Caitlin,

Alfano, Giovanna,

Liu, Zaoqu,

Pan, Teng,

Cao, Lulu,

Ng, Tony

2023

Overview

Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent work has identified that TXNIP has a far wider range of additional roles: from regulating glucose and lipid metabolism, to cell cycle arrest and inflammation. Its expression is increased by stressors commonly found in neoplastic cells and the wider tumor microenvironment (TME), and, as such, TXNIP has been extensively studied in cancers. In this review, we evaluate the current literature regarding the regulation and the function of TXNIP, highlighting its emerging role in modulating signaling between different cell types within the TME. We then assess current and future translational opportunities and the associated challenges in this area. An improved understanding of the functions and mechanisms of TXNIP in cancers may enhance its suitability as a therapeutic target.

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Nature Publishing Group

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