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Predicting Limited Survival After Resection of Synchronous Colorectal Liver Metastases: a Propensity Score Matched Comparison Between The Primary First And The Simultaneous Strategy
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Predicting Limited Survival After Resection of Synchronous Colorectal Liver Metastases: a Propensity Score Matched Comparison Between The Primary First And The Simultaneous Strategy
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Journal Article
Predicting Limited Survival After Resection of Synchronous Colorectal Liver Metastases: a Propensity Score Matched Comparison Between The Primary First And The Simultaneous Strategy
2023
Overview
Background
The best surgical approach to treat synchronous colorectal liver metastases (CRLM) remains unclear. Here, we aimed to identify prognostic factors associated with limited survival comparing patients undergoing primary-first resection (PF) and simultaneous resection (SR) approaches.
Methods
We retrospectively reviewed clinical data of 217 patients who underwent resection for synchronous CRLMs between January 1, 2011, and December 31, 2021. There were 133 (61.2%) PF resection and 84 (38.8%) SRS. The two groups of patients were compared using propensity score matching (PSM) analysis and cox analysis was performed to identify prognostic factors for overall survival (OS).
Results
After PSM, two groups of 71 patients were compared. Patients undergoing SR had longer operative time (324 ± 104 min vs 250 ± 101 min;
p
< 0.0001), similar transfusion (33.3% vs 28.1%;
p
= 0.57), and similar complication rates (35.9% vs 27.2%;
p
= 0.34) than patients undergoing PF. The median overall survival and 5-year survival rates were comparable (
p
= 0.94) between patients undergoing PF (48.2 months and 44%) and patients undergoing SR (45.9 months and 30%). Multivariate Cox analysis identified pre-resection elevated CEA levels (HR: 2.38; 95% CI: 1.20–4.70;
P
= .01), left colonic tumors (HR: 0.34; 95% CI: 0.17–0.68;
P
= .002), and adjuvant treatment (HR: 0.43; 95% CI: 0.22–0.83;
P
= .01) as independent prognostic factors for OS.
Conclusions
In the presence of synchronous CRLM, right colonic tumors, persistent high CEA levels before surgery, and the absence of adjuvant treatment identified patients characterized by a limited survival rate after resection. The approach used (PF vs SR) does not influence short and long-term outcomes.
Publisher
Springer US,Springer Nature B.V
Subject
/ Colorectal Neoplasms - pathology
/ Hepatectomy - adverse effects
/ Humans
/ Liver
/ Medicine
/ Ostomy
/ Patients
/ Surgeons
/ Surgery
/ Tumors
