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Journal Article
Why are tumour blood vessels abnormal and why is it important to know?
2009
Overview
Tumour blood vessels differ from their normal counterparts for reasons that have received little attention. We report here that they are of at least six distinct types, we describe how each forms, and, looking forward, encourage the targeting of tumour vessel subsets that have lost their vascular endothelial growth factor-A (VEGF-A) dependency and so are likely unresponsive to anti-VEGF-A therapies.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Capillaries - physiopathology
/ Humans
/ Neovascularization, Pathologic - drug therapy
/ Neovascularization, Pathologic - etiology
/ Neovascularization, Pathologic - pathology
/ Oncology
/ Tumors
/ Vascular endothelial growth factor
/ Vascular Endothelial Growth Factor A - antagonists & inhibitors
