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Coronin 2B deficiency induces nucleolar stress and neuronal apoptosis
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Coronin 2B deficiency induces nucleolar stress and neuronal apoptosis
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Journal Article
Coronin 2B deficiency induces nucleolar stress and neuronal apoptosis
2024
Overview
In eukaryotes, the nucleolus is the critical non-membranous organelle within nuclei that is responsible for ribosomal DNA (rDNA) transcription and ribosome biogenesis. The transcription of rDNA, a rate-limiting step for ribosome biogenesis, is tightly regulated to meet the demand for global protein synthesis in response to cell physiology, especially in neurons, which undergo rapid changes in morphology and protein composition during development and synaptic plasticity. However, it is unknown how the pre-initiation complex for rDNA transcription is efficiently assembled within the nucleolus in neurons. Here, we report that the nucleolar protein, coronin 2B, regulates rDNA transcription and maintains nucleolar function through direct interaction with upstream binding factor (UBF), an activator of RNA polymerase I transcriptional machinery. We show that coronin 2B knockdown impairs the formation of the transcription initiation complex, inhibits rDNA transcription, destroys nucleolar integrity, and ultimately induces nucleolar stress. In turn, coronin 2B-mediated nucleolar stress leads to p53 stabilization and activation, eventually resulting in neuronal apoptosis. Thus, we identified that coronin 2B coordinates with UBF to regulate rDNA transcription and maintain proper nucleolar function in neurons.
Publisher
Nature Publishing Group UK,Springer Nature B.V,Nature Publishing Group
Subject
/ 38/91
/ 42/109
/ 96/2
/ 96/95
/ Animals
/ Biomedical and Life Sciences
/ Cytology
/ Humans
/ Mice
/ Microfilament Proteins - genetics
/ Microfilament Proteins - metabolism
/ Neurons
/ Nucleoli
/ Pol1 Transcription Initiation Complex Proteins - genetics
/ Pol1 Transcription Initiation Complex Proteins - metabolism
/ Proteins
/ RNA
/ Tumor Suppressor Protein p53 - genetics
/ Tumor Suppressor Protein p53 - metabolism
/ Yeast
