Asset Details
Do you wish to reserve the book?
Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment
Do you wish to request the book?
Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment
2024
Overview
Elevated plasma total homocysteine (tHcy) is associated with the development of Alzheimer's disease and other forms of dementia. In this study, we report the relationship between tHcy and epigenetic age in older adults with mild cognitive impairment from the VITACOG study. Epigenetic age and rate of aging (ROA) were assessed using various epigenetic clocks, including those developed by Horvath and Hannum, DNAmPhenoAge, and with a focus on Index, a new principal component‐based epigenetic clock that, like DNAmPhenoAge, is trained to predict an individual's “PhenoAge.” We identified significant associations between tHcy levels and ROA, suggesting that hyperhomocysteinemic individuals were aging at a faster rate. Moreover, Index revealed a normalization of accelerated epigenetic aging in these individuals following treatment with tHcy‐lowering B‐vitamins. Our results indicate that elevated tHcy is a risk factor for accelerated epigenetic aging, and this can be ameliorated with B‐vitamins. These findings have broad relevance for the sizable proportion of the worldwide population with elevated tHcy. This study uses DNA methylation to evaluate the impact of homocysteine (tHcy) levels on epigenetic age and rate of aging (ROA) in older adults with mild cognitive impairment. Elevated tHcy was associated with faster epigenetic aging, and tHcy‐lowering with B‐vitamins normalized accelerated ROAs in individuals with elevated tHcy.
