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A Randomized Trial of Hyperglycemic Control in Pediatric Intensive Care
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A Randomized Trial of Hyperglycemic Control in Pediatric Intensive Care
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Journal Article
A Randomized Trial of Hyperglycemic Control in Pediatric Intensive Care
2014
Overview
In this trial, critically ill children were randomly assigned to either tight glycemic control or conventional glycemic control. There was no significant between-group difference in major clinical outcomes, although hypoglycemia was more common with tight glycemic control.
Hyperglycemia is a common complication in critical illness and is associated with adverse outcomes.
1
–
5
Single-center, randomized trials have shown that reduction of blood glucose to normal levels with the use of insulin reduces morbidity and mortality among adults in surgical intensive care units (ICUs),
6
with similar effects on morbidity but not on mortality among adults in nonsurgical ICUs.
7
However, two meta-analyses
8
,
9
have failed to show a benefit, and a large, international, multicenter trial showed that tight glycemic control increased mortality.
10
Data on tight glucose control with the use of insulin in critically ill children have been lacking. One . . .
Publisher
Massachusetts Medical Society
Subject
/ Biological and medical sciences
/ Child
/ Children
/ Critical Illness - mortality
/ Diabetes
/ Glucose
/ Heart
/ Hospitalization - statistics & numerical data
/ Humans
/ Hyperglycemia - drug therapy
/ Hypoglycemia - chemically induced
/ Hypoglycemic Agents - administration & dosage
/ Hypoglycemic Agents - adverse effects
/ Infant
/ Insulin
/ Insulin - administration & dosage
