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Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity
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Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity
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Journal Article
Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity
2020
Overview
Observational epidemiological studies indicate that endometriosis and migraine co-occur within individuals more than expected by chance. However, the aetiology and biological mechanisms underlying their comorbidity remain unknown. Here we examined the relationship between endometriosis and migraine using genome-wide association study (GWAS) data. Single nucleotide polymorphism (SNP) effect concordance analysis found a significant concordance of SNP risk effects across endometriosis and migraine GWAS. Linkage disequilibrium score regression analysis found a positive and highly significant genetic correlation (rG = 0.38, P = 2.30 × 10−25) between endometriosis and migraine. A meta-analysis of endometriosis and migraine GWAS data did not reveal novel genome-wide significant SNPs, and Mendelian randomisation analysis found no evidence for a causal relationship between the two traits. However, gene-based analyses identified two novel loci for migraine. Also, we found significant enrichment of genes nominally associated (Pgene < 0.05) with both traits (Pbinomial-test = 9.83 × 10−6). Combining gene-based p-values across endometriosis and migraine, three genes, two (TRIM32 and SLC35G6) of which are at novel loci, were genome-wide significant. Genes having Pgene < 0.1 for both endometriosis and migraine (Pbinomial-test = 1.85 ×10−°3) were significantly enriched for biological pathways, including interleukin-1 receptor binding, focal adhesion-PI3K-Akt-mTOR-signaling, MAPK and TNF-α signalling. Our findings further confirm the comorbidity of endometriosis and migraine and indicate a non-causal relationship between the two traits, with shared genetically-controlled biological mechanisms underlying the co-occurrence of the two disorders.
Publisher
MDPI
Subject
/ Aged
/ Endometriosis - complications
/ etiology
/ Female
/ genes
/ Genetic Predisposition to Disease
/ Genome-Wide Association Study
/ Humans
/ Linkage Disequilibrium - genetics
/ loci
/ Mendelian Randomization Analysis
/ migraine
/ Migraine Disorders - complications
/ Migraine Disorders - genetics
/ Migraine Disorders - pathology
/ mitogen-activated protein kinase
/ Phosphatidylinositol 3-Kinases - genetics
/ Polymorphism, Single Nucleotide - genetics
/ risk
