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Comparison of the effect of isoflurane and propofol on liver regeneration after donor hepatectomy - A randomized controlled trial
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Comparison of the effect of isoflurane and propofol on liver regeneration after donor hepatectomy - A randomized controlled trial
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Journal Article
Comparison of the effect of isoflurane and propofol on liver regeneration after donor hepatectomy - A randomized controlled trial
2025
Overview
The biotransformation of inhalational anesthetic agents can result in production of hepatotoxic metabolites, which may potentially impair liver regeneration. Thus, isoflurane and propofol may have differential impacts on liver regeneration after donor hepatectomy.
To compare the regeneration liver volume (RgLV) via computed tomography (CT) volumetry on post-operative day (POD) 14 in isoflurane and propofol groups.
Randomized controlled pilot trial.
Sixty donors, who underwent donor hepatectomy.
Patients were randomized into isoflurane and propofol group using computer generated random number tables. In isoflurane group, anesthesia was maintained with isoflurane 1–2 % in air‑oxygen mixture. In propofol group, anesthesia was maintained with the target-controlled infusion (TCI) of propofol using a TCI system (Perfusor® Space- B. Braun) at a plasma target concentration of 3–6 μg.ml−1. BIS was recorded in all patients.
Liver CT volumetry was assessed at POD 14.
RgLV on POD14 was comparable in two groups [449.3(170) & 437.8 (177.8) cm3, [Mean Difference (MD) -11.904 95 % Confidence Interval(CI) -101.83, 78.03 respectively; p = 0.79].
Administering propofol or isoflurane may not have differential effect on liver regeneration after donor hepatectomy.
•Hepatotoxic metabolites of inhalational anesthetics may impair liver regeneration.•Regeneration after donor hepatectomy were studied between isoflurane and propofol.•Regeneration volume was comparable between the two groups.•Serum bile acid and Stromal cell derived factor-1 were higher in isoflurane group.•Albumin was lower in isoflurane group than propofol group.
Publisher
Elsevier Inc,Elsevier Limited
Subject
/ Anesthetics, Inhalation - administration & dosage
/ Anesthetics, Inhalation - adverse effects
/ Anesthetics, Inhalation - pharmacology
/ Anesthetics, Intravenous - administration & dosage
/ Anesthetics, Intravenous - adverse effects
/ Epidural
/ Female
/ Fentanyl
/ Hepatectomy - adverse effects
/ Humans
/ Isoflurane - administration & dosage
/ Isoflurane - adverse effects
/ Liver Regeneration - drug effects
/ Male
/ Propofol
/ Propofol - administration & dosage
/ Surgery
