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A simple and inexpensive enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine
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A simple and inexpensive enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine
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Journal Article
A simple and inexpensive enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine
2015
Overview
Understanding the ecology of the gastrointestinal tract and the impact of the contents on the host mucosa is emerging as an important area for defining both wellness and susceptibility to disease. Targeted delivery of drugs to treat specific small intestinal disorders such as small bowel bacterial overgrowth and targeting molecules to interrogate or to deliver vaccines to the remote regions of the small intestine has proven difficult. There is an unmet need for methodologies to release probes/drugs to remote regions of the gastrointestinal tract in furthering our understanding of gut health and pathogenesis. In order to address this concern, we need to know how the regional delivery of a surrogate labeled test compound is handled and in turn, if delivered locally as a liquid or powder, the dynamics of its subsequent handling and metabolism. In the studies we report on in this paper, we chose
13
C sodium acetate (
13
C-acetate), which is a stable isotope probe that once absorbed in the small intestine can be readily measured non-invasively by collection and analysis of
13
CO
2
in the breath. This would provide information of gastric emptying rates and an indication of the site of release and absorptive capacity. In a series of
in vitro
and
in vivo
pig experiments, we assessed the enteric-protective properties of a commercially available polymer EUDRAGIT® L100-55 on gelatin capsules and also on DRcaps®. Test results demonstrated that DRcaps® coated with EUDRAGIT® L100-55 possessed enhanced enteric-protective properties, particularly
in vivo
. These studies add to the body of knowledge regarding gastric emptying in pigs and also begin the process of gathering specifications for the design of a simple and cost-effective enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine.
Publisher
Zhejiang University Press,Springer Nature B.V
Subject
/ Animals
/ Bile Acids and Salts - chemistry
/ Biomedical and Life Sciences
/ Capsules - chemical synthesis
/ China
/ Coated Materials, Biocompatible - chemistry
/ ecology
/ Female
/ gelatin
/ Intestinal Absorption - physiology
/ Macromolecular Substances - administration & dosage
/ Macromolecular Substances - pharmacokinetics
/ mucosa
/ polymers
/ Polymethacrylic Acids - chemistry
/ stomach
/ Swine
/ vaccines
