Journal Article

Multiple Myeloma Cells Express Key Immunoregulatory Cytokines and Modulate the Monocyte Migratory Response

Ramos-Junior, Erivan Schnaider, Morrot, Alexandre, Maiolino, Angelo, Conde, Luciana, Nardy, Ana Flávia Fernandes Ribas, Freire-de-Lima, Leonardo, Santos Lemos, Jéssica, Lima, Juliana Echevarria, Fonseca, Leonardo Marques da

2017

Overview

Multiple myeloma (MM) is a plasma cell disorder that still remains incurable. The immune dysfunction of the host is a striking characteristic of MM, leading to tumor growth and reducing the survival rate of patients. Monocytes are precursors of conventional dendritic cells (DCs), a major player in the immunity mechanisms driving protective T cell responses against tumor. Herein, we report that human MM RPMI 8226 cell line shows a pronounced chemoattractant activity for monocytes and also expresses enhanced levels of the leukocyte chemotactic cytokines CXCL12, CCL5, MIP-1β, and CXCL10 in association with elevated levels of both key immunoregulatory interleukins such as IL-4 and IL-10. This cytokine profile was observed together with reduced expression of IFN-γ by MM RPMI 8226 cell line, a determinant interleukin involved in the acquisition of cellular-mediated protective responses against tumor cells. We further demonstrate that MM RPMI 8226 cell line expresses elevated levels of soluble form of the intercellular adhesion molecule-1 known to inhibit antitumoral T cell responses. This attractive modulation of immune responses by MM cells might provide a means to impair early antitumor responses during the establishment of cytokine-mediated immunosuppressive tumor niche.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Bone marrow / Cell cycle / Chemokines / Cytokines / Dendritic cells / Immune response / immunoregulation / leukocyte migration / Leukocytes / Medicine / monocytes / Multiple myeloma / Pathogenesis / Software