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Changes in peripheral blood inflammatory factors (TNF-α and IL-6) and intestinal flora in AIDS and HIV-positive individuals
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Changes in peripheral blood inflammatory factors (TNF-α and IL-6) and intestinal flora in AIDS and HIV-positive individuals
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Journal Article
Changes in peripheral blood inflammatory factors (TNF-α and IL-6) and intestinal flora in AIDS and HIV-positive individuals
2019
Overview
Objective
In this study, we investigated the changes in peripheral blood inflammatory factors and intestinal flora in acquired immune deficiency syndrome (AIDS) and human immunodeficiency virus (HIV)-positive individuals (AIDS/HIV patients), and explored the relationships among intestinal flora, peripheral blood inflammatory factors, and CD4
+
T lymphocytes.
Methods
Thirty blood and stool samples from an AIDS group and a control group were collected. The levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined by enzyme-linked immunosorbent assay (ELISA), and the number of CD4
+
T lymphocytes by a FACSCount automated instrument. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to determine the messenger RNA (mRNA) levels of
Bifidobacterium
,
Lactobacillus
,
Escherichia coli
,
Enterococcus faecalis
, and
Enterococcus faecium
. Correlations among intestinal flora, inflammatory factor levels, and CD4
+
T lymphocyte values were evaluated using the Spearman correlation coefficient.
Results
The levels of TNF-α and IL-6 in the AIDS group were higher than those in the control group, while the number of CD4
+
T lymphocytes was lower. The amounts of
Bifidobacterium
and
Lactobacillus
in the AIDS group were significantly lower than those in control group, while the amounts of
E. coli
,
E. faecalis
, and
E. faecium
were much higher. The amounts of
Bifidobacterium
and
Lactobacillus
were negatively correlated with the content of TNF-α and IL-6 and the CD4
+
T lymphocyte count, while those correlations were reversed for
E. coli
,
E. faecalis
, and
E. faecium
.
Conclusions
The intestinal microbiota of AIDS/HIV patients were disordered, and there was a correlation between the amount of intestinal flora and the number of CD4
+
T lymphocytes and the levels of TNF-α and IL-6.
Publisher
Zhejiang University Press,Springer Nature B.V
Subject
Acquired immune deficiency syndrome
/ acquired immunodeficiency syndrome
/ Acquired Immunodeficiency Syndrome - immunology
/ Acquired Immunodeficiency Syndrome - microbiology
/ Adult
/ Aged
/ AIDS
/ Biomedical and Life Sciences
/ Blood
/ E coli
/ Enzyme-linked immunosorbent assay
/ feces
/ Female
/ HIV
/ HIV Infections - microbiology
/ Human immunodeficiency virus
/ Humans
/ Male
/ mRNA
/ necrosis
/ patients
/ quantitative polymerase chain reaction
/ reverse transcriptase polymerase chain reaction
/ Tumor Necrosis Factor-alpha - blood
/ Viruses
