Journal Article

Influence of frailty on cardiovascular events and mortality in patients with Chronic Obstructive Pulmonary Disease (COPD): Study protocol for a multicentre European observational study

Verduri, Alessia, Carter, Ben, Hewitt, Jonathan, Clini, Enrico

2024

Overview

Frailty is a clinical state that increases susceptibility to minor stressor events. The risk of frailty is higher in chronic conditions, such as Chronic Obstructive Pulmonary Disease (COPD). Recent studies on COPD have shown that patients living with frailty have an increased risk of mortality. The presence of cardiovascular diseases or conditions are common in COPD and may increase the risk of death. This protocol describes a European prospective cohort study of community-based people, in a stable condition with diagnosis of COPD (as defined by GOLD guidelines) across hospitals in Italy and UK. Frailty prevalence will be assessed using the Clinical Frailty Scale. At 1- and 2-year follow up, primary outcome will be the impact of frailty on the number of cardiovascular events; secondary outcomes: the influence of frailty on cardiovascular mortality, all-cause mortality, and deaths due to COPD. For the primary outcome a zero-inflated Poisson regression will compare the number of cardiovascular events at 1 year. Secondary outcomes will be analysed using the time to mortality. This multicentre study will assess the association between frailty and cardiovascular events and mortality in population with COPD. Data collection is prospective and includes routine clinical data. This research will have important implications for the management of patients with COPD to improve their quality of care, and potentially prognosis. NCT05922202 (www.clinicaltrials.gov).

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Aged / Asthma / Cardiovascular disease / Cardiovascular diseases / Cardiovascular Diseases - mortality / Chronic conditions / Chronic fatigue syndrome / Chronic illnesses / Chronic obstructive pulmonary disease / Clinical medicine / Data collection / Data entry / Europe - epidemiology / Female / Frailty / Frailty - complications / Frailty - mortality / Health care access / Humans / Lung diseases / Lung diseases, Obstructive / Male / Medical care / Medical prognosis / Medical research / Medicine, Experimental / Mortality / Mortality risk / Observational studies / Patient admissions / Patient outcomes / Patients / Personal information / Population studies / Prospective Studies / Pulmonary Disease, Chronic Obstructive - complications / Pulmonary Disease, Chronic Obstructive - mortality / Quality management / Risk / Risk Factors / Smoking / Spirometry / United Kingdom / Vein & artery diseases