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A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa

by Bakayoko, Alima , Sow, Papa-Salif , Kouadio, Alain-Claude , Ouattara, Eric , Anglaret, Xavier , Moh-Semdé, Corinne , Bouhoussou, Franck , Sidibé, Baba , Menan, Hervé , Journot, Valérie , Inwoley, André , Daligou, Marcelle , Konan, Romuald , Gabillard, Delphine , Ndri, Yao , Yao, Abo , Minga, Albert , Séri, Jonas , Bleoué, Gisèle , Babatounde, Nathanael , Kouame, Amadou-Barenson , Makaila, Olewole , Toni, Thomas-d'Aquin , Dohoun, Lambert , Yededji, Sahinou-Yediga , Aoussi, Eba , Hawerlander, Denise , Ahiboh, Hugues , Kabran, Mathieu , Bissagnene, Emmanuel , Koua, Aboli , Dosso, Mireille , Koule, Serge , Sassan-Morokro, Madeleine , Ntakpé, Jean-Baptiste , Koman, Mesmin , Nchot, Célestin , Kouame, Gérard M , Karcher, Sophie , Kouamé, Emmanuel , Gouesse, Patrice , Kanga, Constance , N'Dri-Yoman, Thérèse , Kouamé, Antoine , Aka, Kakou , Mobio, Max , Chenal, Henri , Salamon, Roger , Nzunetu, Gustave , Oussou, Armel , Anzian, Amani , Kadio, Auguste , Amon, Solange , Girard, Pierre-Marie , Chêne, Geneviève , Mahassadi, Alassane , Perronne, Christian , Guéhi, Calixte , Le Carrou, Jérôme , Chaix, Marie-Laure , Bamba, Doféré , Ba-Gomis, Olivier , Oyebi, Mykayila , Ackoundzé, Simpli

in Acquired immune deficiency syndrome / Adult / AIDS / AIDS-Related Opportunistic Infections - prevention & control / Anti-Retroviral Agents - adverse effects / Anti-Retroviral Agents - therapeutic use / Antiretroviral drugs / Antiretroviral therapy / Antitubercular Agents - adverse effects / Antitubercular Agents - therapeutic use / Antiviral agents / Asymptomatic Diseases / Cancer / CD4 antigen / CD4 Lymphocyte Count / Clinical trials / Cote d'Ivoire / Drug therapy / Female / Follow-Up Studies / Hepatitis / HIV / HIV Infections - drug therapy / HIV Infections - immunology / HIV-1 - genetics / HIV-1 - isolation & purification / Human immunodeficiency virus / Humans / Inhibitor drugs / Invasiveness / Isoniazid / Isoniazid - adverse effects / Isoniazid - therapeutic use / Male / Middle Aged / Patients / Preventive medicine / RNA, Viral - analysis / Time-to-Treatment / Tuberculosis / Tuberculosis - prevention & control / Viral Load

2015

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2015

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2015

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Journal Article

A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa

Bakayoko, Alima,

Sow, Papa-Salif,

Kouadio, Alain-Claude,

Ouattara, Eric,

Anglaret, Xavier,

Moh-Semdé, Corinne,

Bouhoussou, Franck,

Sidibé, Baba,

Menan, Hervé,

Journot, Valérie,

Inwoley, André,

Daligou, Marcelle,

Konan, Romuald,

Gabillard, Delphine,

Ndri, Yao,

Yao, Abo,

Minga, Albert,

Séri, Jonas,

Bleoué, Gisèle,

Babatounde, Nathanael,

Kouame, Amadou-Barenson,

Makaila, Olewole,

Toni, Thomas-d'Aquin,

Dohoun, Lambert,

Yededji, Sahinou-Yediga,

Aoussi, Eba,

Hawerlander, Denise,

Ahiboh, Hugues,

Kabran, Mathieu,

Bissagnene, Emmanuel,

Koua, Aboli,

Dosso, Mireille,

Koule, Serge,

Sassan-Morokro, Madeleine,

Ntakpé, Jean-Baptiste,

Koman, Mesmin,

Nchot, Célestin,

Kouame, Gérard M,

Karcher, Sophie,

Kouamé, Emmanuel,

Gouesse, Patrice,

Kanga, Constance,

N'Dri-Yoman, Thérèse,

Kouamé, Antoine,

Aka, Kakou,

Mobio, Max,

Chenal, Henri,

Salamon, Roger,

Nzunetu, Gustave,

Oussou, Armel,

Anzian, Amani,

Kadio, Auguste,

Amon, Solange,

Girard, Pierre-Marie,

Chêne, Geneviève,

Mahassadi, Alassane,

Perronne, Christian,

Guéhi, Calixte,

Le Carrou, Jérôme,

Chaix, Marie-Laure,

Bamba, Doféré,

Ba-Gomis, Olivier,

Oyebi, Mykayila,

Ackoundzé, Simpli

2015

Overview

In this study, early treatment of HIV infection with antiretroviral therapy decreased traditionally HIV-associated and non–HIV-associated complications (at CD4+ counts <800 cells per cubic millimeter), and early isoniazid prophylaxis prevented active tuberculosis. The recommended CD4+ count threshold for starting antiretroviral therapy (ART) in asymptomatic human immunodeficiency virus (HIV)–infected adults in lower-resource countries was increased from 200 cells per cubic millimeter in 2006 to 500 cells per cubic millimeter in 2013. 1 , 2 This change was supported by the results of two randomized, controlled trials. 3 , 4 Meanwhile, three types of arguments have emerged to support even earlier initiation of ART. First, there is increasing documentation of inflammation in people with uncontrolled viral replication and of non–acquired immunodeficiency syndrome (AIDS)–defining noninfectious diseases as causes of death in HIV-infected persons 5 , 6 (with AIDS-defining diseases identified as . . .

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Publisher

Massachusetts Medical Society

Subject

Acquired immune deficiency syndrome

/ Adult

/ AIDS

/ Anti-Retroviral Agents - adverse effects

/ Anti-Retroviral Agents - therapeutic use

/ Antiretroviral drugs

/ Antiretroviral therapy