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Trial of Nemolizumab in Moderate-to-Severe Prurigo Nodularis

by Yosipovitch, Gil , Piketty, Christophe , Ständer, Sonja , Narbutt, Joanna , Legat, Franz J , Misery, Laurent , Bieber, Thomas , Lacour, Jean-Philippe , Wollenberg, Andreas , Ahmad, Faiz , Paul, Carle , Reich, Adam

in Adult / Aged / Aged, 80 and over / Antibodies, Monoclonal, Humanized - adverse effects / Antibodies, Monoclonal, Humanized - therapeutic use / Body weight / Chronic illnesses / Clinical trials / Cytokines / Dermatitis / Dermatology / Diarrhea / Double-Blind Method / Female / Gastrointestinal Diseases - chemically induced / Humans / Injections, Subcutaneous / Male / Middle Aged / Monoclonal antibodies / Muscular Diseases - chemically induced / Nodules / Patient Acuity / Patients / Prurigo - complications / Prurigo - drug therapy / Pruritus / Pruritus - drug therapy / Pruritus - etiology / Quality of life / Signal transduction / Skin / Skin diseases / Skin lesions / Sleep / Young Adult

2020

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Trial of Nemolizumab in Moderate-to-Severe Prurigo Nodularis

2020

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Trial of Nemolizumab in Moderate-to-Severe Prurigo Nodularis

2020

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Journal Article

Trial of Nemolizumab in Moderate-to-Severe Prurigo Nodularis

Yosipovitch, Gil,

Piketty, Christophe,

Ständer, Sonja,

Narbutt, Joanna,

Legat, Franz J,

Misery, Laurent,

Bieber, Thomas,

Lacour, Jean-Philippe,

Wollenberg, Andreas,

Ahmad, Faiz,

Paul, Carle,

Reich, Adam

2020

Overview

In patients with prurigo nodularis, a severely pruritic skin disorder, the subcutaneously administered interleukin-31 receptor antibody nemolizumab was tested in a 12-week, phase 2 trial. The intensity of itching and overall severity of the disorder were more greatly reduced with nemolizumab than with placebo.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Aged

/ Aged, 80 and over

/ Antibodies, Monoclonal, Humanized - adverse effects

/ Antibodies, Monoclonal, Humanized - therapeutic use

/ Body weight

/ Chronic illnesses