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Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease

by Murphy, Sabina A. , Baum, Seth J. , López, J. Antonio G. , Lepor, Norman E. , Wang, Huei , O’Donoghue, Michelle L. , Wu, You , Ran, Xinhui , Kassahun, Helina , Rosenson, Robert S. , Gencer, Baris , Gaudet, Daniel , Kuder, Julia F. , Sabatine, Marc S. , Knusel, Beat , Stout, Elmer

in Adverse events / Anticholesteremic Agents - administration & dosage / Anticholesteremic Agents - adverse effects / Anticholesteremic Agents - pharmacology / Anticholesteremic Agents - therapeutic use / Apolipoproteins / Arteriosclerosis / Atherosclerosis - drug therapy / Cardiology / Cardiology General / Cardiovascular disease / Cardiovascular diseases / Cardiovascular Diseases - drug therapy / Cholesterol / Clinical trials / Confidence intervals / Coronary Disease / Double-Blind Method / Double-blind studies / Ezetimibe - therapeutic use / Genetics / Genetics General / Humans / Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use / Hypercholesterolemia - drug therapy / Kexin / Laboratories / Lipids / Lipoprotein(a) - analysis / Lipoprotein(a) - antagonists & inhibitors / Liver - drug effects / Liver - metabolism / Low density lipoprotein / Myocardial Infarction / PCSK9 Inhibitors - therapeutic use / Placebos / Proprotein convertases / Risk factors / RNA Therapeutics / RNA, Small Interfering - administration & dosage / RNA, Small Interfering - adverse effects / RNA, Small Interfering - pharmacology / RNA, Small Interfering - therapeutic use / siRNA / Statistical analysis / Subtilisin

2022

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Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease

2022

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2022

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Journal Article

Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease

Murphy, Sabina A.,

Baum, Seth J.,

López, J. Antonio G.,

Lepor, Norman E.,

Wang, Huei,

O’Donoghue, Michelle L.,

Wu, You,

Ran, Xinhui,

Kassahun, Helina,

Rosenson, Robert S.,

Gencer, Baris,

Gaudet, Daniel,

Kuder, Julia F.,

Sabatine, Marc S.,

Knusel, Beat,

Stout, Elmer

2022

Overview

Lipoprotein(a) is similar to LDL cholesterol but contains apolipoprotein(a). A trial tested the effects of an oligonucleotide drug targeting apo(a) mRNA on lipoprotein(a) concentrations in patients with CVD.

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Publisher

Massachusetts Medical Society

Subject

Adverse events

/ Anticholesteremic Agents - administration & dosage

/ Anticholesteremic Agents - adverse effects

/ Anticholesteremic Agents - pharmacology

/ Anticholesteremic Agents - therapeutic use

/ Apolipoproteins

/ Arteriosclerosis