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Characterization of a cDNA Encoding a 34-kDa Purkinje Neuron Protein Recognized by Sera from Patients with Paraneoplastic Cerebellar Degeneration
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Characterization of a cDNA Encoding a 34-kDa Purkinje Neuron Protein Recognized by Sera from Patients with Paraneoplastic Cerebellar Degeneration
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Characterization of a cDNA Encoding a 34-kDa Purkinje Neuron Protein Recognized by Sera from Patients with Paraneoplastic Cerebellar Degeneration
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Journal Article
Characterization of a cDNA Encoding a 34-kDa Purkinje Neuron Protein Recognized by Sera from Patients with Paraneoplastic Cerebellar Degeneration
1989
Overview
Paraneoplastic cerebellar degeneration is a neurological disorder of unknown cause occurring in patients with an identified or occult cancer. An autoimmune etiology is likely since autoantibodies directed against the Purkinje cells of the cerebellum have been found in the serum and cerebrospinal fluid of some patients. Two Purkinje cell-specific antigens are recognized by these autoantibodies, a major antigen of 62 kDa (CDR 62, cerebellar degeneration-related 62-kDa protein) and a minor antigen of 34 kDa (CDR 34). Our previous studies have described the isolation and characterization of a human cerebellar cDNA that encodes an epitope recognized by sera from patients with paraneoplastic cerebellar degeneration. We have now established by two independent methods that this gene is uniquely expressed in Purkinje cells of the cerebellum and corresponds to the minor antigen CDR 34. This antigen is also expressed in tumor tissue from a patient with paraneoplastic cerebellar degeneration.
Publisher
National Academy of Sciences of the United States of America,National Acad Sciences
Subject
550201 - Biochemistry- Tracer Techniques
/ ANTIGENS
/ Autoimmunity (experimental aspects and models)
/ Biological and medical sciences
/ BODY
/ BRAIN
/ Cerebellar Diseases - genetics
/ Cerebellar Diseases - immunology
/ DISEASES
/ DNA
/ ELECTRON CAPTURE RADIOISOTOPES
/ ETIOLOGY
/ Fundamental and applied biological sciences. Psychology
/ genes
/ Humans
/ ISOTOPES
/ man
/ Nerve Tissue Proteins - genetics
/ Neurons
/ NUCLEI
/ ORGANS
/ paraneoplastic cerebellar degeneration
/ Paraneoplastic Syndromes - genetics
/ Paraneoplastic Syndromes - immunology
/ PATIENTS
/ Recombinant Fusion Proteins - immunology
/ serum
/ STRUCTURAL CHEMICAL ANALYSIS
/ Tumors
