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Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox

by Weidenthaler, Heinz , Maclennan, Jane , Hornung, Joachim , Lee, HeeChoon S , Koca, Craig , Schmidt, Darja , Samy, Nathaly , Pittman, Phillip R , Silbernagl, Günter , Heery, Christopher R , Hahn, Matthew , Meyer, Thomas P.H , Chaplin, Paul

in Adolescent / Adult / Antibodies / Antibodies, Neutralizing - blood / Antibodies, Viral - blood / Armed forces / Clinical trials / Female / Humans / Immune response / Immunity (Disease) / Infectious diseases / Male / Medical research / R&D / Research & development / Research centers / Seroconversion / Smallpox / Smallpox - immunology / Smallpox - prevention & control / Smallpox Vaccine - adverse effects / Smallpox Vaccine - immunology / Treatment Outcome / Vaccines / Vaccines, Attenuated - adverse effects / Vaccines, Attenuated - immunology / Vaccinia / Vaccinia virus - immunology / Young Adult

2019

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Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox

2019

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Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox

2019

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Journal Article

Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox

Weidenthaler, Heinz,

Maclennan, Jane,

Hornung, Joachim,

Lee, HeeChoon S,

Koca, Craig,

Schmidt, Darja,

Samy, Nathaly,

Pittman, Phillip R,

Silbernagl, Günter,

Heery, Christopher R,

Hahn, Matthew,

Meyer, Thomas P.H,

Chaplin, Paul

2019

Overview

A candidate vaccine against smallpox, modified vaccinia Ankara, was studied in 440 participants. MVA elicited immune responses similar to those associated with the established vaccinia-based vaccine and attenuated vaccinia replication in a human challenge model.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adult

/ Antibodies

/ Antibodies, Neutralizing - blood

/ Antibodies, Viral - blood

/ Armed forces

/ Clinical trials