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Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy
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Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy
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Journal Article
Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy
2015
Overview
In this double-blind, placebo-controlled trial involving 2854 patients with Chagas' cardiomyopathy, no clinical benefit was found with 2 to 3 months of benznidazole therapy during 5 years of followup.
Chagas’ disease is the third most common parasitic disease globally, after malaria and schistosomiasis.
1
Chagas’ cardiomyopathy is the most common form of nonischemic cardiomyopathy and one of the leading causes of complications and death in Latin America.
2
An estimated 6 million to 7 million persons are infected, and 36,800 new cases occur each year. Chagas’ cardiomyopathy develops in approximately 25% of patients infected with
Trypanosoma cruzi
.
3
–
5
Chagas’ disease has two phases: acute and chronic. Acute infection is usually a self-limited febrile illness.
6
In the chronic phase, cardiac or digestive complications develop in approximately one third of patients two . . .
Publisher
Massachusetts Medical Society
Subject
/ Aged
/ Antigens
/ Cardiovascular Diseases - etiology
/ Chagas Cardiomyopathy - complications
/ Chagas Cardiomyopathy - drug therapy
/ Chagas Cardiomyopathy - mortality
/ Female
/ Genotype
/ Humans
/ Male
/ Nitroimidazoles - adverse effects
/ Nitroimidazoles - therapeutic use
/ Patients
/ Protozoa
/ Stroke
/ Trypanocidal Agents - adverse effects
/ Trypanocidal Agents - therapeutic use
/ Trypanosoma cruzi - genetics
