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Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function
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Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function
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Journal Article
Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function
2015
Overview
This study showed a lower frequency of delayed graft function in kidneys from deceased donors who were randomly assigned to receive mild hypothermia than in those from donors assigned to normothermia.
Delayed graft function, which is defined as the requirement for dialysis in the recipient within 7 days after renal transplantation,
1
results in increased health care expenditures and decreased long-term graft function.
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–
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Delayed graft function is reported in up to 50% of renal allografts recovered from donors after declaration of death according to neurologic criteria (brain-dead donors).
7
,
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Randomized, controlled trials to study the effect of therapeutic hypothermic protection in donors on renal-graft function in transplant recipients are lacking.
Therapeutic hypothermia, also termed targeted temperature management, is an established intervention that is used to protect neurologic function in patients with . . .
