Asset Details
Do you wish to reserve the book?
Baseline cognition and demographic, lifestyle, and cardiovascular risk factors in US POINTER
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Baseline cognition and demographic, lifestyle, and cardiovascular risk factors in US POINTER
Do you wish to request the book?
Baseline cognition and demographic, lifestyle, and cardiovascular risk factors in US POINTER
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Baseline cognition and demographic, lifestyle, and cardiovascular risk factors in US POINTER
2025
Overview
INTRODUCTION Validation of the primary cognitive composite and baseline cognitive characteristics are presented for the US‐Study‐to‐Protect‐Brain‐Health‐Through‐Lifestyle‐Intervention‐to‐Reduce‐Risk (US POINTER). METHODS US POINTER is a multicenter, randomized clinical trial of two lifestyle interventions testing cognitive benefit in older adults without significant cognitive impairment but at‐risk for decline due to well‐established factors. Cognition is measured using a global cognitive composite (US POINTER modified Neuropsychological Test Battery‐PmNTB). RESULTS The PmNTB is a valid cognitive composite, exhibiting good psychometric properties and tracking with other established outcomes. Among the 2111 enrolled participants (mean age = 68.2 years, 69% women, 31% from race and ethnic minoritized groups), demographic characteristics alone (age, sex, education, race, ethnicity) explained more variance in cognition measured using the PmNTB (25.94%) compared with cardiovascular and family history risk factors combined (added < 3% explained variance). DISCUSSION In a large diverse older adult cohort, demographic features rather than well‐established risks for cognitive decline correlate with baseline global cognition. Clinical trial registration number: NCT03688126 Highlights Demographic characteristics explain baseline cognition in at‐risk older adults. The POINTER Modified Neuropsychological Test Battery (PmNTB) is a valid measure. Worse cognition tracks with E4+, high HbA1c, current smoking, Framingham heart risk.
Publisher
John Wiley and Sons Inc
