Journal Article

The influence of systemic-to-pulmonary arterial shunts and peripheral vasculatures in univentricular circulations: Focus on coronary perfusion and aortic arch hemodynamics through computational multi-domain modeling

Hsia, Tain-Yen, Pennati, Giancarlo, Corsini, Chiara, Migliavacca, Francesco

2018

Overview

Initial palliation for univentricular hearts can be achieved via a systemic-to-pulmonary shunt (SPS). SPS configurations differ depending on the proximal anastomosis location, which might lead to dissimilar coronary and upper body perfusions. Mathematical modeling can be used to explore the local and global hemodynamic effects of the SPSs. In literature there are few patient-specific models of SPS that specifically address the influence of both the local and peripheral vasculature. In this study, multi-domain models of univentricular circulations were developed to investigate local hemodynamics and flow distribution in the presence of two shunt configurations. We also analyzed the relative impact of local and peripheral vascular resistances on coronary perfusion and flows through the upper aortic branches. A two-step approach was followed. First, two patient-specific models were based on clinical data collected from univentricular patients having different shunts and peripheral vasculatures. Each model coupled a three-dimensional representation of SPS, aortic arch (AA) and pulmonary arteries, with a lumped parameter model (LPM) of peripheral vasculature closing the circulatory loop. Then, two additional models of hypothetical subjects were created by coupling each customized LPM with the other patient’s three-dimensional anatomy. Flow rates and pressures predicted by the patient-specific models revealed overall agreement with clinical data. Differences in the local hemodynamics were seen during diastole between the two models. Varying the three-dimensional models, while keeping an identical LPM, led to comparable flow distribution through the AA, suggesting that peripheral vasculatures have a dominant effect on local hemodynamics with respect to the shunt configuration.

• Publisher: Elsevier Ltd,Elsevier Limited
• Subject: Anastomosis / Aorta, Thoracic - physiopathology / Aortic arch / Arteries / Bypasses / Computer applications / Configurations / Coronary Circulation / Diastole / Flow distribution / Flow velocity / Fluid dynamics / Fluid-structure interaction / Fontan Procedure / Heart Defects, Congenital - physiopathology / Heart Defects, Congenital - surgery / Heart Ventricles - pathology / Heart Ventricles - physiopathology / Hemodynamics / Humans / Impact analysis / Lumped parameter model / Mathematical models / Models, Cardiovascular / Norwood palliation / Palliation / Patient-specific model / Patients / Perfusion / Pulmonary arteries / Pulmonary artery / Pulmonary Artery - physiopathology / Pulmonary Artery - surgery / Shunts / Single ventricle / Three dimensional flow / Three dimensional models / Vascular resistance / Veins & arteries