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Are we repeating mistakes of the past? A review of the evidence for esketamine
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Are we repeating mistakes of the past? A review of the evidence for esketamine
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Journal Article
Are we repeating mistakes of the past? A review of the evidence for esketamine
2021
Overview
Esketamine has been licensed for ‘treatment-resistant depression’ in the USA, UK and Europe. Licensing trials did not establish efficacy: two trials were negative, one showed a statistically significant but clinically uncertain effect, and a flawed discontinuation trial was included, against Food and Drug Administration precedent. Safety signals – deaths, including suicides, and bladder damage – were minimised.
Publisher
Cambridge University Press
