Journal Article

Children's oppositional defiant disorder symptoms and neural synchrony in mother-child interactions: An fNIRS study

Zhang, Wenrui, Duan, Lian, Chi, Peilian, Lin, Xiuyun, Zhou, Nan, He, Ting

2024

Overview

•The mother-child dyads of ODD children exhibit lower neural synchrony across of parent-child interactions (positive, negative, and neutral).•The neural synchrony between mother and child was negatively associated ODD symptoms in children.•Various neural synchronies (positive, negative, and neutral) between mother and child all play a role in the network of ODD symptoms in children. Interpersonal neural synchrony (INS) between mothers and children responds to the temporal similarity of brain signals in joint behavior between dyadic partners and is considered an important neural indicator of the formation of adaptive social interaction bonds. Parent-child interactions are particularly important for the development and maintenance of oppositional defiant disorder (ODD) in children, but the underlying neurocognitive mechanisms are unknown. Therefore, in the current study we measured INS between mothers and children in interactions by using simultaneous functional Near-infrared Spectroscopy (fNIRS), and explored its association with ODD symptoms in children. Seventy-two mother-child dyads were recruited to participate in the study, including 35 children with ODD and 37 healthy children to be used as a control. Each mother-child dyad was measured for neural activity in frontal, parietal, and temporal lobe regions while completing free-play as well as positive, and negative topic discussion tasks. We used Phase-locked value to calculate the synchrony strength and then used the K-means algorithm and k-space based alignment tests to confirm the specific patterns of parent-child synchrony in different brain areas. The results showed that, in free-play (right MFG and bilateral SFG), positive (left TPJ and bilateral SFGdor), and negative (bilateral SFGmed, right ANG, and left MFG) topic discussions, the mother-child pairs showed different patterns of INS. These specific INS patterns were significantly lower in the ODD group compared to the control group and were negatively associated with ODD symptoms in children. Network analyses showed that these INS patterns were connected to different nodes in the ODD symptom network. Our findings suggest that ODD mother-child dyads exhibit lower neural synchrony across a wide range of parent-child interactions. Neural synchrony in the context of interpersonal interactions provides new insights into understanding the neural mechanisms of ODD and can be used as an indicator of neural and socio-environmental factors in the network of psychological disorder symptoms.

• Publisher: Elsevier Inc,Elsevier Limited,Elsevier
• Subject: Adult / Behavior / Brain research / Child / Children / Children & youth / Cognition / Cooperation / Emotions / Environmental factors / Female / fNIRS / Humans / Hyperscanning / Infrared spectroscopy / Male / Mental disorders / Mother-Child Relations / Mothers / Neural synchrony / Neurodevelopmental disorders / Neuropsychology / Oppositional defiant disorder / Oppositional Defiant Disorder - diagnostic imaging / Oppositional Defiant Disorder - physiopathology / Parent-child interaction / Parents & parenting / Social behavior / Social interaction / Spectroscopy, Near-Infrared - methods / Temporal lobe / Verbal communication