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Liberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome

by Constantin, Jean-Michel , Quenot, Jean-Pierre , Louis, Guillaume , Barrot, Loic , Asfar, Pierre , Capellier, Gilles , Winiszewski, Hadrien , Bouhemad, Belaid , Levy, Bruno , Vettoretti, Lucie , Collange, Olivier , Souweine, Bertrand , Badie, Julio , Pottecher, Julien , Mauny, Frederic , Pili-Floury, Sebastien , Montini, Florent , Puyraveau, Marc

in Adult / Aged / Blood pressure / Clinical trials / Consent / Conservative Treatment / Female / Humans / Intensive care / Intubation / Ischemia / Life Sciences / Male / Mechanical ventilation / Middle Aged / Mortality / Oxygen / Oxygen - administration & dosage / Oxygen - blood / Oxygen Inhalation Therapy - methods / Oxygen therapy / Oxygenation / Patients / Respiration, Artificial - methods / Respiratory distress syndrome / Respiratory Distress Syndrome, Adult - therapy / Respiratory therapy / Statistical analysis / Survival Analysis / Time Factors / Treatment Outcome / Ventilators / Weaning

2020

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Liberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome

2020

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2020

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Journal Article

Liberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome

Constantin, Jean-Michel,

Quenot, Jean-Pierre,

Louis, Guillaume,

Barrot, Loic,

Asfar, Pierre,

Capellier, Gilles,

Winiszewski, Hadrien,

Bouhemad, Belaid,

Levy, Bruno,

Vettoretti, Lucie,

Collange, Olivier,

Souweine, Bertrand,

Badie, Julio,

Pottecher, Julien,

Mauny, Frederic,

Pili-Floury, Sebastien,

Montini, Florent,

Puyraveau, Marc

2020

Overview

Patients with acute respiratory distress syndrome received conservative oxygen therapy or liberal oxygen therapy for 7 days. The trial was prematurely stopped because of futility and safety concerns. Mortality at day 28 was 34.3% in the conservative-oxygen group and 26.5% in the liberal-oxygen group. Five mesenteric ischemic events occurred, all in the conservative-oxygen group.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Aged

/ Blood pressure

/ Clinical trials

/ Consent

/ Conservative Treatment

/ Female