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The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection
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The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection
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Journal Article
The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection
2020
Overview
The RTS,S/AS01 vaccine provides partial protection against
infection but determinants of protection and/or disease are unclear. Previously, anti-circumsporozoite protein (CSP) antibody titers and blood RNA signatures were associated with RTS,S/AS01 efficacy against controlled human malaria infection (CHMI). By analyzing host blood transcriptomes from five RTS,S vaccination CHMI studies, we demonstrate that the transcript ratio MX2/GPR183, measured 1 day after third immunization, discriminates protected from non-protected individuals. This ratiometric signature provides information that is complementary to anti-CSP titer levels for identifying RTS,S/AS01 immunized people who developed protective immunity and suggests a role for interferon and oxysterol signaling in the RTS,S mode of action.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Antibodies, Protozoan - immunology
/ Genes
/ Humans
/ Immunogenicity, Vaccine - genetics
/ Malaria
/ Malaria Vaccines - immunology
/ Malaria, Falciparum - genetics
/ Malaria, Falciparum - immunology
/ Malaria, Falciparum - parasitology
/ Malaria, Falciparum - prevention & control
/ Myxovirus Resistance Proteins - genetics
/ Plasmodium falciparum - immunology
/ Protozoan Proteins - immunology
/ Receptors, G-Protein-Coupled - genetics
/ RNA-Seq
/ Vaccines
