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Specific control of Arabidopsis BAK1/SERK4-regulated cell death by protein glycosylation
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Specific control of Arabidopsis BAK1/SERK4-regulated cell death by protein glycosylation
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Journal Article
Specific control of Arabidopsis BAK1/SERK4-regulated cell death by protein glycosylation
2016
Overview
Precise control of cell death is essential for the survival of all organisms.
Arabidopsis thaliana
BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 (BAK1) and somatic embryogenesis receptor kinase 4 (SERK4) redundantly and negatively regulate cell death through elusive mechanisms. By deploying a genetic screen for suppressors of cell death triggered by virus-induced gene silencing of
BAK1/SERK4
on
Arabidopsis
knockout collections, we identified STT3a, a protein involved in
N
-glycosylation modification, as an important regulator of
bak1/serk4
cell death. Systematic investigation of glycosylation pathway and endoplasmic reticulum (ER) quality control (ERQC) components revealed distinct and overlapping mechanisms of cell death regulated by BAK1/SERK4 and their interacting protein BIR1. Genome-wide transcriptional analysis revealed the activation of members of cysteine-rich receptor-like kinase (
CRK
) genes in the
bak1/serk4
mutant. Ectopic expression of
CRK4
induced STT3a/
N-
glycosylation-dependent cell death in
Arabidopsis
and
Nicotiana benthamiana
. Therefore,
N
-glycosylation and specific ERQC components are essential to activate
bak1/serk4
cell death, and CRK4 is likely to be among client proteins of protein glycosylation involved in BAK1/SERK4-regulated cell death.
Control of cell death is crucial for plant life. A comprehensive screen for suppressors of BAK1/SERK4-mediated cell death identified a component of protein glycosylation pathways and ERQC, and its cysteine-rich receptor-like kinase (CRK) targets.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 49/91
/ 82/29
/ 96/109
/ 96/44
/ 96/47
/ Arabidopsis Proteins - genetics
/ Arabidopsis Proteins - metabolism
/ Biomedical and Life Sciences
/ Cysteine
/ Gene Expression Regulation, Plant
/ Genomes
/ Kinases
/ Mutation
/ Protein Kinases - metabolism
/ Protein-Serine-Threonine Kinases - genetics
/ Protein-Serine-Threonine Kinases - metabolism
/ Proteins
