Journal Article

Comparison Between Magnetic Resonance Imaging and Computed Tomography in the Detection and Volumetric Assessment of Lung Nodules: A Prospective Study

Delacoste, Jean, Long, Olivier, Darçot, Emeline, Simons, Julien, Jreige, Mario, Gidoin Tuyet Van, Stacey, Casutt, Alessio, Buela, Flore, Prior, John O., Beigelman-Aubry, Catherine, Rotzinger, David C., Ledoux, Jean-Baptiste, Lovis, Alban

2022

Overview

Computed tomography (CT) lung nodule assessment is routinely performed and appears very promising for lung cancer screening. However, the radiation exposure through time remains a concern. With the overall goal of an optimal management of indeterminate lung nodules, the objective of this prospective study was therefore to evaluate the potential of optimized ultra-short echo time (UTE) MRI for lung nodule detection and volumetric assessment. Eight (54.9 ± 13.2 years) patients with at least 1 non-calcified nodule ≥4 mm were included. UTE under high-frequency non-invasive ventilation (UTE-HF-NIV) and in free-breathing at tidal volume (UTE-FB) were investigated along with volumetric interpolated breath-hold examination at full inspiration (VIBE-BH). Three experienced readers assessed the detection rate of nodules ≥4 mm and ≥6 mm, and reported their location, 2D-measurements and solid/subsolid nature. Volumes were measured by two experienced readers. Subsequently, two readers assessed the detection and volume measurements of lung nodules ≥4mm in gold-standard CT images with soft and lung kernel reconstructions. Volumetry was performed with lesion management software (Carestream, Rochester, New York, USA). UTE-HF-NIV provided the highest detection rate for nodules ≥4 mm ( = 66) and ≥6 mm ( = 32) (35 and 50%, respectively). No dependencies were found between nodule detection and their location in the lung with UTE-HF-NIV ( > 0.4), such a dependency was observed for two readers with VIBE-BH ( = 0.002 and 0.03). Dependencies between the nodule's detection and their size were noticed among readers and techniques ( < 0.02). When comparing nodule volume measurements, an excellent concordance was observed between CT and UTE-HF-NIV, with an overestimation of 13.2% by UTE-HF-NIV, <25%-threshold used for nodule's growth, conversely to VIBE-BH that overestimated the nodule volume by 28.8%. UTE-HF-NIV is not ready to replace low-dose CT for lung nodule detection, but could be used for follow-up studies, alternating with CT, based on its volumetric accuracy.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Chronic obstructive pulmonary disease / CT nodule detection / Fourier transforms / high-frequency noninvasive ventilation / Lung cancer / lung MRI / Magnetic resonance imaging / Medical screening / Medicine / Morphology / MR nodule detection / nodule volume assessment / Oxygen saturation / Patients / Radiation / Scanners