Journal Article

Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy

Oliveira, Aline A., Patente, Thiago A., Bergami-Santos, Patrícia C., Pinho, Mariana P., Evangelista, Gabriela C. M., Barbuto, José A. M.

2019

Overview

Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve T cell activation and effector differentiation. They are, likewise, involved in the induction and maintenance of immune tolerance in homeostatic conditions. Their phenotypic and functional heterogeneity points to their great plasticity and ability to modulate, according to their microenvironment, the acquired immune response and, at the same time, makes their precise classification complex and frequently subject to reviews and improvement. This review will present general aspects of the DC physiology and classification and will address their potential and actual uses in the management of human disease, more specifically cancer, as therapeutic and monitoring tools. New combination treatments with the participation of DC will be also discussed.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Animals / Antigen-presenting cells / Antigens / Biomarkers / cancer combination therapies / Cancer immunotherapy / Cancer Vaccines / Cell activation / Cell Differentiation / Chemokines / Combined Modality Therapy / Cytokines / Dendritic cells / Dendritic Cells - cytology / Dendritic Cells - immunology / Dendritic Cells - metabolism / human dendritic cells / Humans / Immune response / Immune system / Immune System - immunology / Immune System - metabolism / Immune System Phenomena / Immunological tolerance / Immunology / Immunotherapy / Lymphocytes / Lymphocytes T / Microenvironments / mo-DC / monocyte-derived dendritic cells / Neoplasms - immunology / Neoplasms - pathology / Neoplasms - therapy / Pathogens / Phenotype / Treatment Outcome / Tumor Microenvironment - immunology