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Human T Cell Response to Dengue Virus Infection
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Human T Cell Response to Dengue Virus Infection
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Journal Article
Human T Cell Response to Dengue Virus Infection
2019
Overview
DENV is a major public health problem worldwide, thus underlining the overall significance of the proposed Program. The four dengue virus (DENV) serotypes (1-4) cause the most common mosquito-borne viral disease of humans, with 3 billion people at risk for infection and up to 100 million cases each year, most often affecting children. The protective role of T cells during viral infection is well-established. Generally, CD8 T cells can control viral infection through several mechanisms, including direct cytotoxicity, and production of pro-inflammatory cytokines such as IFN-γ and TNF-α. Similarly, CD4 T cells are thought to control viral infection through multiple mechanisms, including enhancement of B and CD8 T cell responses, production of inflammatory and anti-viral cytokines, cytotoxicity, and promotion of memory responses. To probe the phenotype of virus-specific T cells, epitopes derived from viral sequences need to be known. Here we discuss the identification of CD4 and CD8 T cell epitopes derived from DENV and how these epitopes have been used by researchers to interrogate the phenotype and function of DENV-specific T cell populations.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ CD4-Positive T-Lymphocytes - immunology
/ CD4-Positive T-Lymphocytes - pathology
/ CD8-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - pathology
/ dengue
/ Epitopes
/ Epitopes, T-Lymphocyte - immunology
/ Humans
/ Interferon-gamma - immunology
/ Peptides
/ Proteins
/ Tumor Necrosis Factor-alpha - immunology
/ vaccine
/ Vaccines
/ Viruses
