Journal Article

Urtica dioica extracts abolish scopolamine-induced neuropathies in rats

Hammad, Seddik, Alkahtani, Saad, Hassan, Mohamed K., Aleya, Lotfi, Ahmed, Hassan, Mahmoud, Ghada A., Ali, Elham H. A., Abdel-Daim, Mohamed M., Mosaad, Rehab M., Anber, Nahla, Abu Almaaty, Ali H.

2021

Overview

Alzheimer’s disease (AD) is characterized by alterations in monoamines, oxidative stress, and metabolic dysfunctions. We aim to assess the therapeutic impacts of roots or leaf extract from Urtica dioica (UD; stinging nettle) against scopolamine (SCOP)-induced memory dysfunction, amnesia, and oxidative stress in rats. Spatial memory was assessed by Y maze test. Tissue analyses of norepinephrine (NE), dopamine (DA), serotonin (5-HT), malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH, GSSG), AMP, ADP, and ATP were assessed by HPLC. mRNA levels of Tau and Hsp70 were estimated by PCR. UD extracts particularly nettle root (NR) significantly normalized the SCOP-induced memory deficits even more potent than sermion (SR) and donepezil (DON). Similarly, NR had potent therapeutic impacts on the levels of cortical and hippocampal monoamines e.g. DA, NE, and 5-HT. SCOP induced a dramatic oxidative stress as measured by MDA, NO, and GSSG levels; however, UD extracts showed significant anti-oxidative stress impacts. Additionally, UD extracts restored ATP levels and reduced the levels of AMP and ADP compared to SCOP-treated rats. Furthermore, cortical Tau and hippocampal Hsp70 were modulated by UD extracts particularly NR compared to the SCOP group. In conclusion, UD extracts particularly roots have potential therapeutic impacts against SCOP-induced neuroinflammatory and/or Alzheimer-like phenotype in rats.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V,Springer Verlag
• Subject: Adenosine diphosphate / Alzheimer's disease / Amnesia / AMP / Animals / Aquatic Pollution / Donepezil / Dopamine / Earth and Environmental Science / Ecotoxicology / Environment / Environmental Chemistry / Environmental Health / Environmental science / Environmental Sciences / Glutathione / High-performance liquid chromatography / Hippocampus / Hsp70 protein / Inflammation / leaf extracts / Liquid chromatography / Malondialdehyde / Memory tasks / Monoamines / mRNA / Neurodegenerative diseases / Neuropathy / Nitric oxide / Norepinephrine / Oxidative Stress / peripheral nervous system diseases / phenotype / Phenotypes / Plant Extracts / pollution / Rats / Research Article / Roots / Scopolamine / Serotonin / Spatial analysis / Spatial memory / Tau protein / therapeutics / Tissue analysis / Urtica dioica / Waste Water Technology / Water Management / Water Pollution Control