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Human collagen XV is a prominent histopathological component of sinusoidal capillarization in hepatocellular carcinogenesis
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Human collagen XV is a prominent histopathological component of sinusoidal capillarization in hepatocellular carcinogenesis
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Human collagen XV is a prominent histopathological component of sinusoidal capillarization in hepatocellular carcinogenesis
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Journal Article
Human collagen XV is a prominent histopathological component of sinusoidal capillarization in hepatocellular carcinogenesis
2016
Overview
Background
Increased expression of collagen XV has been reported in hepatocellular carcinogenesis in mice. The aim of this study was to confirm the previous murine findings in human hepatocellular carcinoma (HCC) specimens, along with the histopathological distribution of collagen XV in tumoral tissues.
Methods
Sixty-three primary HCC specimens were examined. Immunostaining of collagen XV and quantitative reverse transcriptional PCR of
COL15A1
, which encodes collagen XV, were performed.
Results
Positive staining of collagen XV was observed in all tumoral regions, regardless of differentiation level or pathological type of HCC, along the sinusoid-like endothelium, whereas collagen XV was not expressed in any non-tumoral region. The intensity score of collagen XV immunostaining and the mRNA value of
COL15A1
were significantly correlated.
COL15A1
expression in tumors was 3.24-fold higher than in non-tumoral regions. Multivariate analysis showed that
COL15A1
expression was significantly higher in the absence of hepatitis virus and moderately differentiated HCC.
Conclusions
COL15A1
mRNA was up-regulated in HCC and collagen XV was expressed along the sinusoid-like endothelium of HCC but not in non-tumoral regions, which implies that collagen XV contributes to the capillarization of HCC.
Publisher
Springer Science and Business Media LLC,Springer Japan,Springer Nature B.V
