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Plasma calprotectin in chronically dialyzed end-stage renal disease patients
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Plasma calprotectin in chronically dialyzed end-stage renal disease patients
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Journal Article
Plasma calprotectin in chronically dialyzed end-stage renal disease patients
2010
Overview
Objective The current study aimed to evaluate plasma calprotectin levels and clearance end-stage renal disease (ESRD) patients with and without acute infection undergoing chronic hemodialysis (HD). Materials and methods Blood samples from 54 HD patients were obtained before and after the HD and 42 healthy blood donors were examined as controls. The blood levels of calprotectin, procalcitonin, C-reactive protein (CRP), and intracellular production of interleukins 10 and 12 in monocytes were determined in both groups. Results The concentrations of plasma calprotectin in ESRD patients were significantly higher than in healthy controls (p < 0.05). No differences between pre- and post-HD calprotectin plasma levels were observed (p = 0.07 for two-tailed test). Plasma calprotectin levels were not significantly influenced by the presence of acute infection (p = 0.19) or diabetes (p = 0.42). A significant positive correlation of plasma calprotectin to plasma beta-2 microglobulin was proven (p < 0.05). Procalcitonin (PCT), CRP, IL-10, and IL-12 were not correlated with plasma calprotectin before or after HD. The elevation of plasma calprotectin was correlated strongly to the hemodialysis vintage (r = 0.55, p < 0.01). Conclusions Significantly elevated levels of plasma calprotectin in ESRD patients occur without an acute infectious cause and are not affected by the presence of diabetes. By analogy to plasma beta-2 microglobulin, a close relation of plasma calprotectin to HD vintage was shown.
Publisher
Basel : SP Birkhäuser Verlag Basel,SP Birkhäuser Verlag Basel,Springer Nature B.V
Subject
/ beta 2-Microglobulin - metabolism
/ Biomedical and Life Sciences
/ C-Reactive Protein - metabolism
/ Calcitonin Gene-Related Peptide
/ Enzyme-Linked Immunosorbent Assay
/ Female
/ Humans
/ Interleukin-10 - biosynthesis
/ Interleukin-12 - biosynthesis
/ Kidney Failure, Chronic - blood
/ Leukocyte L1 Antigen Complex - blood
/ Male
