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The bacterial microbiome of Dermacentor andersoni ticks influences pathogen susceptibility
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Journal Article
The bacterial microbiome of Dermacentor andersoni ticks influences pathogen susceptibility
2016
Overview
Ticks are of medical importance owing to their ability to transmit pathogens to humans and animals. The Rocky Mountain wood tick,
Dermacentor andersoni
, is a vector of a number of pathogens, including
Anaplasma marginale,
which is the most widespread tick-borne pathogen of livestock. Although ticks host pathogenic bacteria, they also harbor bacterial endosymbionts that have a role in tick physiology, survival, as well as pathogen acquisition and transmission. The goal of this study was to characterize the bacterial microbiome and examine the impact of microbiome disruption on pathogen susceptibility. The bacterial microbiome of two populations of
D. andersoni
with historically different susceptibilities to
A. marginale
was characterized. In this study, the microbiome was disrupted and then ticks were exposed to
A. marginale
or
Francisella novicida
to determine whether the microbiome correlated with pathogen susceptibility. Our study showed that an increase in proportion and quantity of
Rickettsia bellii
in the microbiome was negatively correlated to
A. marginale
levels in ticks. Furthermore, a decrease in
Francisella
endosymbionts was associated with lower
F. novicida
infection levels, demonstrating a positive pathogen–endosymbiont relationship. We demonstrate that endosymbionts and pathogens have varying interactions, and suggest that microbiome manipulation may provide a possible method for biocontrol by decreasing pathogen susceptibility of ticks.
Publisher
Nature Publishing Group UK,Oxford University Press,Nature Publishing Group
