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Immunotherapy for Hepatocellular Carcinoma: A 2021 Update

by Vailas, Michail , Moris, Dimitrios , Karamouzis, Michalis V. , Gkotsis, Efthymios , Kole, Christo , Charalampakis, Nikolaos , Tsakatikas, Sergios , Schizas, Dimitrios , Kykalos, Stylianos

in Angiogenesis / Antigens / Apoptosis / Cancer vaccines / Chemoradiotherapy / Chemotherapy / Clinical trials / Cytokines / Cytotoxicity / Dendritic cells / Drug dosages / Drug resistance / Drug therapy / FDA approval / Hepatocellular carcinoma / Hepatoma / Immunotherapy / Kinases / Ligands / Liver cancer / Liver diseases / Liver transplantation / Lymphocytes / Malignancy / Medical prognosis / Melanoma / Metastases / Mortality / Non-small cell lung carcinoma / Patient outcomes / Patients / Proteins / Radiofrequency ablation / Review / Solid tumors / Surgery / Transplants & implants / Tumor microenvironment / Tumors / Vaccines / Vascular endothelial growth factor

2020

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Immunotherapy for Hepatocellular Carcinoma: A 2021 Update

by Vailas, Michail , Moris, Dimitrios , Karamouzis, Michalis V. , Gkotsis, Efthymios , Kole, Christo , Charalampakis, Nikolaos , Tsakatikas, Sergios , Schizas, Dimitrios , Kykalos, Stylianos

2020

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Immunotherapy for Hepatocellular Carcinoma: A 2021 Update

by Vailas, Michail , Moris, Dimitrios , Karamouzis, Michalis V. , Gkotsis, Efthymios , Kole, Christo , Charalampakis, Nikolaos , Tsakatikas, Sergios , Schizas, Dimitrios , Kykalos, Stylianos

2020

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Journal Article

Immunotherapy for Hepatocellular Carcinoma: A 2021 Update

Vailas, Michail,

Moris, Dimitrios,

Karamouzis, Michalis V.,

Gkotsis, Efthymios,

Kole, Christo,

Charalampakis, Nikolaos,

Tsakatikas, Sergios,

Schizas, Dimitrios,

Kykalos, Stylianos

2020

Overview

Hepatocellular carcinoma (HCC) is one of one of the most frequent liver cancers and the fourth leading cause of cancer-related mortality worldwide. Current treatment options such as surgery, neoadjuvant chemoradiotherapy, liver transplantation, and radiofrequency ablation will benefit only a very small percentage of patients. Immunotherapy is a novel treatment approach representing an effective and promising option against several types of cancer. The aim of our study is to present the currently ongoing clinical trials and to evaluate the efficacy of immunotherapy in HCC. In this paper, we demonstrate that combination of different immunotherapies or immunotherapy with other modalities results in better overall survival (OS) and progression-free survival (PFS) compared to single immunotherapy agent. Another objective of this paper is to demonstrate and highlight the importance of tumor microenvironment as a predictive and prognostic marker and its clinical implications in immunotherapy response.

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MDPI AG,MDPI

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